Electrospinning of biomimetic fibrous scaffolds for tissue engineering: a review

被引：65

作者：

Tan, George Z. ^{[1
]}

Zhou, Yingge ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Ind Mfg & Syst Engn, Lubbock, TX 79409 USA

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 15期

关键词：

Biomimetic scaffolds; electrospinning; nanofiber; tissue engineering; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; OF-THE-ART; NANOFIBROUS SCAFFOLDS; OSTEOGENIC DIFFERENTIATION; IN-VITRO; 3-DIMENSIONAL SCAFFOLDS; HYDROGEL SCAFFOLD; DRUG-DELIVERY;

D O I：

10.1080/00914037.2019.1636248

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds. Specifically, we focus on scaffolds with gradients in element and structure, 3 D nanofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers. Future directions of electrospinning research for tissue engineering are to realize the full potential of integrating the tunable 3 D fibrous microarchitecture in scaffold manufacturing at a clinically relevant scale, and to develop novel micro- and nano-scaffold architecture with modulated functionality for optimal tissue regeneration. [GRAPHICS] .

引用

页码：947 / 960

页数：14

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