Optimal techniques for arterial gene transfer

被引：32

作者：

Feldman, LJ ^{[1
]}

Steg, G ^{[1
]}

机构：

[1] HOP BICHAT, U460 INSERM, FAC XAVIER BICHAT, F-75877 PARIS, FRANCE

来源：

CARDIOVASCULAR RESEARCH | 1997年 / 35卷 / 03期

关键词：

gene therapy; atherosclerosis; adenovirus; liposomes; catheter; restenosis; angiogenesis; plaque stabilization;

D O I：

10.1016/S0008-6363(97)00148-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular gene therapy is becoming a clinical reality due to improved vectors, delivery systems and careful experimental validation studies. Nearly all cardiovascular diseases are amenable to gene therapy, but the optimal combination of vector, delivery system and therapeutic gene is likely to be unique to each application. Currently, the most efficient vectors available are replication-defective adenoviral vectors, but transgene expression is limited in time due to a strong immune response. Conversely, non-viral Vectors or plasmid DNA. may be used safely but have very limited efficiency. Percutaneous, catheter-based delivery is feasible for most applications. The ultimate issues that will decide of the future of gene therapy are safety of the transfer and delivery techniques as well as cost/effectiveness comparisons with alternative therapies, including local delivery of drugs, proteins and/or mechanical devices. (C) 1997 Elsevier Science B.V.

引用

页码：391 / 404

页数：14

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