A Retrospective Review of the Prognostic Value of ALDH-1, Bmi-1 and Nanog Stem Cell Markers in Esophageal Squamous Cell Carcinoma

被引：27

作者：

Hwang, Cheng-Cheng ^{[1
]}

Nieh, Shin ^{[2
,3
,4
]}

Lai, Chien-Hong ^{[5
]}

Tsai, Chien-Sheng ^{[6
]}

Chang, Liang-Che ^{[1
]}

Hua, Chung-Ching ^{[7
]}

Chi, Wen-Ying ^{[1
]}

Chien, Hui-Ping ^{[1
]}

Wang, Chih-Wei ^{[9
]}

Chan, Siu-Cheung ^{[8
]}

Hsieh, Tsan-Yu ^{[1
]}

Chen, Jim-Ray ^{[1
]}

机构：

[1] Chang Gung Mem Hosp, Dept Pathol, Keelung, Taiwan

[2] Natl Def Med Ctr, Dept Pathol, Taipei, Taiwan

[3] Natl Def Med Ctr, Grad Inst Pathol, Taipei, Taiwan

[4] Tri Serv Gen Hosp, Taipei, Taiwan

[5] Chang Gung Mem Hosp, Dept Internal Med, Div Hematol Oncol, Keelung, Taiwan

[6] Chang Gung Mem Hosp, Dept Radiat Oncol, Keelung, Taiwan

[7] Chang Gung Mem Hosp, Div Pulm Crit Care & Sleep Med, Keelung, Taiwan

[8] Chang Gung Mem Hosp, Dept Diagnost Radiol, Keelung, Taiwan

[9] Chang Gung Mem Hosp, Dept Anat Pathol, Taoyuan, Taiwan

来源：

PLOS ONE | 2014年 / 9卷 / 08期

关键词：

GENE-EXPRESSION; CANCER; CHEMORADIOTHERAPY; HETEROGENEITY; METASTASIS; SURVIVAL; TARGET; BREAST;

D O I：

10.1371/journal.pone.0105676

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. Immunohistochemistry was used to measure the expression of ALDH-1, Bmi-1, and Nanog in ESCC tissues from 41 patients who received pre-operative chemoradiation. We evaluated the relationship between expression of these markers, and clinicopathological features, tumor regression grade (TRG), and 5-year overall survival (OS). There were no significant associations of ALDH-1 or Bmi-1 expression with age, gender, clinical stage, and treatments (p>0.05). However, patients with Nanog-positive tumors were significantly older than those whose tumors were Nanog-negative (p = 0.033). TRG after treatment was significantly associated with expression of ALDH-1 (p = 0.001), Bmi-1 (p = 0.004), and Nanog (p<0.001). Although OS was significantly better in patients with low TRGs (p = 0.001), there were no significant correlations between ALDH-1, Bmi-1, or Nanog with OS. Expression of ALDH-1, Bmi-1, and Nanog correlated with TRG, but not OS. Further large studies are necessary to fully elucidate the prognostic value of these stem cell markers for ESCC patients.

引用

页数：7

共 33 条

[1] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].