Methylphenidate Significantly Reduces Lapses of Attention During On-Road Highway Driving in Patients With ADHD

被引:7
作者
Verster, Joris C. [1 ,2 ]
Roth, Thomas [3 ]
机构
[1] Univ Utrecht, Div Pharmacol, Utrecht Inst Pharmaceut Sci, NL-3584 CG Utrecht, Netherlands
[2] Swinburne Univ, Ctr Human Psychopharmacol, Melbourne, Vic, Australia
[3] Henry Ford Hlth Syst, Sleep Disorders & Res Ctr, Detroit, MI USA
关键词
ADHD; methylphenidate; driving; lapses; SDLP; DEFICIT HYPERACTIVITY DISORDER; DEFICIT/HYPERACTIVITY DISORDER; PERFORMANCE; ADULTS; IMPACT;
D O I
10.1097/JCP.0000000000000174
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lapses of attention are characteristic for attention-deficit/hyperactivity disorder (ADHD) and as such may impair performance of daily activities. Data from an on-road driving study were reanalyzed to determine lapses in patients with ADHD after treatment with methylphenidate and placebo. A total of 18 adult ADHD patients performed a 100-km on-road driving test and were instructed to drive with a steady lateral position and constant speed. The SD of lateral position (SDLP), that is, the weaving of the car, lapses, and alertness, was assessed. Driving was significantly better (P = 0.006) with methylphenidate (SDLP, 18.8 cm) when compared with placebo (SDLP, 21.2 cm). Both the reduction in SDLP and the number of lapses (P = 0.003) confirm this significant improvement, which is further supported by subjective assessments of perceived driving performance. Although lapses were common in the placebo condition (11/18 patients), they were much less frequently observed (5/18 patients) after treatment with methylphenidate. Postdriving assessments suggest that lapses often go unnoticed by drivers. In conclusion, methylphenidate significantly improves driving of patients with ADHD by significantly reducing the number of lapses.
引用
收藏
页码:633 / 636
页数:4
相关论文
共 17 条
[1]   Driving in young adults with attention deficit hyperactivity disorder: Knowledge, performance, adverse outcomes, and the role of executive functioning [J].
Barkley, RA ;
Murphy, KR ;
Dupaul, GJ ;
Bush, T .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2002, 8 (05) :655-672
[2]   The impact of secondary task cognitive processing demand on driving performance [J].
Blanco, Myra ;
Biever, Wayne J. ;
Gallagher, John P. ;
Dingus, Thomas A. .
ACCIDENT ANALYSIS AND PREVENTION, 2006, 38 (05) :895-906
[3]   Driver performance in the moments surrounding a microsleep [J].
Boyle, Linda Ng ;
Tippin, Jon ;
Paul, Amit ;
Rizzo, Matthew .
TRANSPORTATION RESEARCH PART F-TRAFFIC PSYCHOLOGY AND BEHAVIOUR, 2008, 11 (02) :126-136
[4]   Adult Attention-Deficit/Hyperactivity Disorder and Driving: Why and How to Manage It [J].
Cox, Daniel J. ;
Madaan, Vishal ;
Cox, Brian S. .
CURRENT PSYCHIATRY REPORTS, 2011, 13 (05) :345-350
[5]   SHORT-FORM OF THE PROFILE OF MOOD STATES (POMS-SF) - PSYCHOMETRIC INFORMATION [J].
CURRAN, SL ;
ANDRYKOWSKI, MA ;
STUDTS, JL .
PSYCHOLOGICAL ASSESSMENT, 1995, 7 (01) :80-83
[6]   Impact of totally and partially predictive alert in distracted and undistracted subjects: An event related potential study [J].
Fort, Alexandra ;
Collette, Boris ;
Bueno, Mercedes ;
Deleurence, Philippe ;
Bonnard, Arnaud .
ACCIDENT ANALYSIS AND PREVENTION, 2013, 50 :578-586
[7]   DEVELOPMENT OF THE ADDICTION RESEARCH-CENTER INVENTORY (ARCI) - SELECTION OF ITEMS THAT ARE SENSITIVE TO THE EFFECTS OF VARIOUS DRUGS [J].
HAERTZEN, CA ;
HILL, HE ;
BELLEVILLE, RE .
PSYCHOPHARMACOLOGIA, 1963, 4 (03) :155-166
[8]  
Jerome L, 2006, J CAN ACAD CHILD ADO, V15, P105
[9]  
Klauer SG, 2006, 810594 NHTSA DOT HS
[10]  
Louwerens J., 1987, ALCOHOL DRUGS TRAF T, V86, P183