Superantigens - powerful modifiers of the immune system

被引：125

作者：

Fraser, J ^{[1
]}

Arcus, V ^{[1
]}

Kong, P ^{[1
]}

Baker, E ^{[1
]}

Proft, T ^{[1
]}

机构：

[1] Univ Auckland, Sch Biol Sci, Dept Mol Med, Auckland, New Zealand

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 03期

关键词：

D O I：

10.1016/S1357-4310(99)01657-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superantigens are powerful microbial toxins that activate the immune system by binding to class II major histocompatibility complex and T-cell receptor molecules. They cause a number of diseases characterized by fever and shock and are important virulence factors for two human commensal organisms, Staphylococcus aureus and Streptococcus pyogenes, as well as for some viruses. Their mode of action and variation around the common theme of over-stimulating T cells, provides a rich insight into the constant battle between microbes and the immune system.

引用

页码：125 / 132

页数：8

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