CXCR4 Expression Accounts for Clinical Phenotype and Outcome in Acute Myeloid Leukemia

被引：23
作者：
Mannelli, Francesco [1 ]
Cutini, Ilaria
Gianfaldoni, Giacomo
Bencini, Sara
Scappini, Barbara
Pancani, Fabiana
Ponziani, Vanessa
Bonetti, Maria Ida
Biagiotti, Caterina
Longo, Giovanni
Bosi, Alberto
机构：
[1] Ist Toscano Tumori, I-50134 Florence, Italy
来源：
CYTOMETRY PART B-CLINICAL CYTOMETRY | 2014年 / 86卷 / 05期
关键词：
acute myeloid leukemia; immunophenotype; CXCR4; NPM1; prognosis; CHEMOKINE RECEPTOR CXCR4; STEM-CELL NICHE; MUTATIONS; OVEREXPRESSION; CLASSIFICATION; PROGNOSIS; ADVERSE; NPM1;
D O I：
10.1002/cyto.b.21156
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: In acute myeloid leukemia (AML), CXCR4 expression has been correlated with leukocytosis and prognosis. Methods: We quantified CXCR4 expression by flow cytometry on leukemic cells in 142 AML patients. Results: We confirm a correlation between high CXCR4 expression and leukemic burden. Furthermore, we documented a correlation with platelet count, dysplastic megakaryopoiesis, hepato-splenomegaly and extra-hematological disease. NPM1-mutated AML displayed a significantly higher intensity of CXCR4 compared to NPM1-wt cases: it is conceivable its clinical phenotype to be driven by high CXCR4 expression. Conclusions: CXCR4 expression resulted in an independent prognostic factor. Our data support CXCR4 targeting as a potential therapeutic strategy. (C) 2014 International Clinical Cytometry Society
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收藏
页码：340 / 349
页数：10
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