Single molecule analysis by biological nanopore sensors

被引:86
作者
Ying, Yi-Lun [1 ]
Cao, Chan [1 ]
Long, Yi-Tao [1 ]
机构
[1] E China Univ Sci & Technol, Dept Chem, Shanghai, Peoples R China
关键词
ALPHA-HEMOLYSIN NANOPORE; DNA-PACKAGING NANOMOTOR; NANOMETER-SCALE PORE; PROTEIN NANOPORE; MEMBRANE-CHANNEL; NUCLEIC-ACIDS; STOCHASTIC DETECTION; UNZIPPING KINETICS; STRANDED-DNA; ION-CHANNEL;
D O I
10.1039/c4an00706a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Nanopore sensors provide a highly innovative technique for a rapid and label-free single molecule analysis, which holds a great potential in routing applications. Biological nanopores have been used as ultra-sensitive sensors over a wide range of single molecule analysis including DNA sequencing, disease diagnosis, drug screening, environment monitoring and the construction of molecule machines. This mini review will focus on the current strategies for the identification and characterization of an individual analyte, especially based on our recent achievements in biological nanopore biosensors.
引用
收藏
页码:3826 / 3835
页数:10
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