One-pot synthesis of n-alkyl substituted phosphoryl guanidines

被引:5
作者
de Souza, MC
de Macedo, WP
da Silva, MCM
Ramos, GCD
Alt, HG
机构
[1] Univ Fed Fluminense, Inst Quim Organ, BR-24020150 Rio De Janeiro, Brazil
[2] Univ Bayreuth, Bayreuth, Germany
关键词
N-alkyl guanidines; phosphoramidic acid; phosphoryl guanidines;
D O I
10.1080/10436500490459669
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
This article describes an attractive and one-pot synthesis of the title compound by phosphorylation of just prepared N-substituted guanidines from cyanamide and the desired amine. The method allows a variety of N-substituents to hang on the final phosphoryl guanidine as a function of the wider availability of commercial simple amines.
引用
收藏
页码:1047 / 1054
页数:8
相关论文
共 8 条
[1]   PHOSPHORUS-NITROGEN COMPOUNDS XXIII - ONCOLYTIC PHOSPHORYLATED IMINES [J].
CATES, LA ;
LI, VS .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (03) :308-311
[2]   New symmetric diisopropylphosphoryl-S-alkanedi yldiisothioureas. Investigations on their synthesis [J].
De Souza, MC ;
Ohara, AK ;
Araripe, DR ;
Dias, PD ;
Kuwata, JC .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1999, 148 :143-148
[3]  
LIN WO, 1995, QUIM NOVA, V18, P431
[4]   SYNTHESIS AND PRELIMINARY COMPLEXATION STUDIES OF DIALKYLPHOSPHORYLTHIOUREA AND GUANIDINES [J].
LIN, WO ;
GUIMARAES, CN ;
DESOUZA, MC ;
DACOSTA, JBN ;
ALT, HG .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1994, 92 (1-4) :1-9
[5]   Symmetric and asymmetric diisopropoxyphosphoryl guanidines [J].
Lin, WO ;
De Souza, MC ;
De Amorim, L ;
Alt, HG .
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2000, 163 :65-75
[6]  
MCCOMBIE H, 1945, J CHEM SOC, V380
[7]   Effect of homologous interleukin-1, interleukin-6 and tumor necrosis factor-α on the core body temperature of mice [J].
Wang, JP ;
Ando, T ;
Dunn, AJ .
NEUROIMMUNOMODULATION, 1997, 4 (5-6) :230-236
[8]   SYNTHESIS OF THE BIDENTATE ORGANOPHOSPHORUS COMPOUNDS WITH AN UREA SUBSTITUENTS [J].
XI, SK ;
ZHAO, YF ;
LIN, WO ;
DESOUZA, MC .
SYNTHETIC COMMUNICATIONS, 1990, 20 (21) :3295-3301