Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

被引：831

作者：

Wajnberg, Ania ^{[1
]}

Amanat, Fatima ^{[2
,3
]}

Firpo, Adolfo ^{[4
]}

Altman, Deena R. ^{[5
]}

Bailey, Mark J. ^{[1
]}

Mansour, Mayce ^{[1
]}

McMahon, Meagan ^{[2
]}

Meade, Philip ^{[2
,3
]}

Mendu, Damodara Rao ^{[4
]}

Muellers, Kimberly ^{[1
]}

Stadlbauer, Daniel ^{[2
]}

Stone, Kimberly ^{[1
]}

Strohmeier, Shirin ^{[2
]}

Simon, Viviana ^{[2
]}

Aberg, Judith ^{[5
]}

Reich, David L. ^{[6
]}

Krammer, Florian ^{[2
]}

Cordon-Cardo, Carlos ^{[4
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Gen Internal Med, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Pathol, Clin Microbiol Lab, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Div Infect Dis, Dept Med, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Dept Anesthesiol Perioperat & Pain Med, New York, NY 10029 USA

来源：

SCIENCE | 2020年 / 370卷 / 6521期

基金：

美国国家卫生研究院;

关键词：

PROTECTION; ASSAYS;

D O I：

10.1126/science.abd7728

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.

引用

页码：1227 / +

页数：4

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