Engineering the bioelectrochemical interface using functional nanomaterials and microchip technique toward sensitive and portable electrochemical biosensors

被引:87
作者
Jia, Xiaofang [1 ]
Dong, Shaojun [1 ]
Wang, Erkang [1 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
基金
中国国家自然科学基金;
关键词
Electrochemical; Biosensors; Nanomaterials; Microfluidic chip; Aptamer; Cytosensor; Enzyme; Biofuel cell; ORDERED MESOPOROUS CARBONS; SOLID-STATE ELECTROCHEMILUMINESCENCE; GOLD NANOPARTICLE HYBRIDS; SENSING PLATFORM; ELECTRODE MATERIAL; HYDROGEN-PEROXIDE; BIOFUEL CELLS; NUCLEIC-ACID; FUEL-CELLS; IN-VITRO;
D O I
10.1016/j.bios.2015.05.037
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Electrochemical biosensors have played active roles at the forefront of bioanalysis because they have the potential to achieve sensitive, specific and low-cost detection of biomolecules and many others. Engineering the electrochemical sensing interface with functional nanomaterials leads to novel electrochemical biosensors with improved performances in terms of sensitivity, selectivity, stability and simplicity. Functional nanomaterials possess good conductivity, catalytic activity, biocompatibility and high surface area. Coupled with bio-recognition elements, these features can amplify signal transduction and biorecognition events, resulting in highly sensitive biosensing. Additionally, microfluidic electrochemical biosensors have attracted considerable attention on account of their miniature, portable and low-cost systems as well as high fabrication throughput and ease of scaleup. For example, electrochemical enzymetic biosensors and aptamer biosensors (aptasensors) based on the integrated microchip can be used for portable point-of-care diagnostics and environmental monitoring. This review is a summary of our recent progress in the field of electrochemical biosensors, including aptasensors, cytosensors, enzymatic biosensors and self-powered biosensors based on biofuel cells. We presented the advantages that functional nanomaterials and microfluidic chip technology bring to the electrochemical biosensors, together with future prospects and possible challenges. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:80 / 90
页数:11
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