Shapes of dominant transition paths from single-molecule force spectroscopy

被引：37

作者：

Makarov, Dmitrii E. ^{[1
,2
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

[2] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA

来源：

JOURNAL OF CHEMICAL PHYSICS | 2015年 / 143卷 / 19期

基金：

美国国家科学基金会;

关键词：

ENERGY LANDSCAPES; PROTEIN; DIFFUSION; TRAJECTORIES; COEFFICIENTS; DYNAMICS; RATES; TIMES;

D O I：

10.1063/1.4935706

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Recent single molecule measurements of biomolecular folding achieved the time resolution sufficient for observation of individual transition paths. This note discusses several ways in which transition path ensembles can be statistically analyzed to extract a single, "typical" transition path. Analytical approximations derived here for such a transition path further allow one to estimate dynamical parameters (such as the intramolecular diffusion coefficient) directly from the transition path shapes. (C) 2015 AIP Publishing LLC.

引用

页数：4

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