Expression of Squamous Cell Carcinoma Markers and Adenocarcinoma Markers in Primary Pulmonary Neuroendocrine Carcinomas

被引：0
作者：
Masai, Kyohei [1 ,2 ]
Tsuta, Koji [1 ]
Kawago, Mitsumasa [1 ,2 ]
Tatsumori, Takahiro [1 ]
Kinno, Tomoaki [1 ]
Taniyama, Tomoko [1 ]
Yoshida, Akihiko [1 ]
Asamura, Hisao [2 ]
Tsuda, Hitoshi [1 ]
机构：
[1] Natl Canc Ctr, Div Pathol & Clin Lab, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Dept Thorac Surg, Tokyo 1040045, Japan
来源：
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2013年 / 21卷 / 04期
关键词：
neuroendocrine tumor; lung; immunohistochemical marker; TRANSCRIPTION FACTOR-I; NONSMALL CELL; LUNG-CANCER; TISSUE MICROARRAY; DIFFERENTIAL-DIAGNOSIS; IMMUNOHISTOCHEMICAL MARKERS; MONOCLONAL-ANTIBODIES; BIOPSY SPECIMENS; P63; EXPRESSION; CYTOKERATINS;
D O I：
暂无
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Recent clinical trials have revealed that accurate histologic typing of non-small cell lung cancer is essential. Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. SOX2 (76.2%) had the greatest expression for NECs. CK5/6 (1.4%), desmocollin 3 (0.5%), and napsin A (0%) were expressed less or not at all in NECs. Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. In our study, CK5/6 and desmocollin 3 were highly specific markers for SQC, and napsin A was highly specific for ADC. These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer.
引用
收藏
页码：292 / 297
页数：6
相关论文
共 37 条
  • [1] ANG DC, 2010, MODERN PATHOL, V23, pA379
  • [2] [Anonymous], 2004, PATHOLOGY GENETICS T
  • [3] [Anonymous], 1999, HIST TYP LUNG PLEUR
  • [4] p63 expression in lung carcinoma - A tissue microarray study of 408 cases
    Au, NHC
    Gown, AM
    Cheang, M
    Huntsman, D
    Yorida, E
    Elliott, WM
    Flint, J
    English, J
    Gilks, CB
    Grimes, HL
    [J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2004, 12 (03) : 240 - 247
  • [5] p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma
    Bishop, Justin A.
    Teruya-Feldstein, Julie
    Westra, William H.
    Pelosi, Giuseppe
    Travis, William D.
    Rekhtman, Natasha
    [J]. MODERN PATHOLOGY, 2012, 25 (03) : 405 - 415
  • [6] BROERS JLV, 1988, CANCER RES, V48, P3221
  • [7] Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas
    Camilo, R
    Capelozzi, VL
    Siqueira, SAC
    Del Carlo Bernardi, F
    [J]. HUMAN PATHOLOGY, 2006, 37 (05) : 542 - 546
  • [8] Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens
    Chhieng, DC
    Cangiarella, JF
    Zakowski, MF
    Goswami, S
    Cohen, JM
    Yee, HT
    [J]. CANCER CYTOPATHOLOGY, 2001, 93 (05): : 330 - 336
  • [9] Desmoglein 3 as a prognostic factor in lung cancer
    Fukuoka, Junya
    Dracheva, Tatiana
    Shih, Joanna H.
    Hewitt, Stephen M.
    Fujii, Takashi
    Kishor, Aparna
    Mann, Felecia
    Shilo, Konstantin
    Franks, Teri J.
    Travis, William D.
    Jen, Jin
    [J]. HUMAN PATHOLOGY, 2007, 38 (02) : 276 - 283
  • [10] Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation
    Gontan, Cristina
    de Munck, Anne
    Vermeij, Marcel
    Grosveld, Frank
    Tibboel, Dick
    Rottier, Robbert
    [J]. DEVELOPMENTAL BIOLOGY, 2008, 317 (01) : 296 - 309
1234