Expression of Squamous Cell Carcinoma Markers and Adenocarcinoma Markers in Primary Pulmonary Neuroendocrine Carcinomas

被引：1

作者：

Masai, Kyohei ^{[1
,2
]}

Tsuta, Koji ^{[1
]}

Kawago, Mitsumasa ^{[1
,2
]}

Tatsumori, Takahiro ^{[1
]}

Kinno, Tomoaki ^{[1
]}

Taniyama, Tomoko ^{[1
]}

Yoshida, Akihiko ^{[1
]}

Asamura, Hisao ^{[2
]}

Tsuda, Hitoshi ^{[1
]}

机构：

[1] Natl Canc Ctr, Div Pathol & Clin Lab, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Dept Thorac Surg, Tokyo 1040045, Japan

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2013年 / 21卷 / 04期

关键词：

neuroendocrine tumor; lung; immunohistochemical marker; TRANSCRIPTION FACTOR-I; NONSMALL CELL; LUNG-CANCER; TISSUE MICROARRAY; DIFFERENTIAL-DIAGNOSIS; IMMUNOHISTOCHEMICAL MARKERS; MONOCLONAL-ANTIBODIES; BIOPSY SPECIMENS; P63; EXPRESSION; CYTOKERATINS;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Recent clinical trials have revealed that accurate histologic typing of non-small cell lung cancer is essential. Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). We analyzed the expression of 8 markers [p63, cytokeratin (CK) 5/6, SOX2, CK7, desmocollin 3, thyroid transcription factor-1 (8G7G3/1 and SPT24), and napsin A] in 224 NECs. SOX2 (76.2%) had the greatest expression for NECs. CK5/6 (1.4%), desmocollin 3 (0.5%), and napsin A (0%) were expressed less or not at all in NECs. Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. In our study, CK5/6 and desmocollin 3 were highly specific markers for SQC, and napsin A was highly specific for ADC. These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer.

引用

页码：292 / 297

页数：6

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