Nalbuphine in pediatric anesthesia

被引：25
作者：
Schultz-Machata, A. -M. [1 ]
Becke, K. [2 ]
Weiss, M. [3 ]
机构：
[1] Med Univ Wien, Klin Abt Allgemeine Anasthesie & Intens Med, Univ Klin Anasthesie Allgemeine Intens Med & Schm, A-1090 Vienna, Austria
[2] Klin Hallerwiese Cnopfsche Kinderklin, Abt Anasthesie & Intens Med, Nurnberg, Germany
[3] Univ Kinderkliniken, Anasthesieabt, Zurich, Switzerland
来源：
ANAESTHESIST | 2014年 / 63卷 / 02期
关键词：
Anesthesia; Analgesics; opioid; Perioperative care; Pain; Drug administration routes; INDUCED RESPIRATORY DEPRESSION; PATIENT-CONTROLLED ANALGESIA; COMMON BILE-DUCT; POSTOPERATIVE PAIN; REGIONAL ANESTHESIA; AGONIST-ANTAGONIST; SPONTANEOUS MOVEMENTS; INTRAVENOUS MORPHINE; PROPOFOL ANESTHESIA; INTRANASAL FENTANYL;
D O I：
10.1007/s00101-014-2293-z
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Efficient and safe pediatric perioperative pain therapy in the context of a multimodal pain therapy concept requires a slight to moderate opioid analgesic. Nalbuphine is a nearly ideal opioid for this purpose due to its unique pharmacological properties as a mu-receptor antagonist/kappa-receptor agonist and a high safety profile. Nalbuphine is used clinically primarily in postoperative pain therapy administered as a bolus, continuous infusion and patient-controlled analgesia. Furthermore, it is administered in different regimens for pediatric diagnostic and interventional sedation.
引用
收藏
页码：135 / 143
页数：9
相关论文
共 81 条
[1]  
[Anonymous], 2009, SCHMERZTHERAPIE BEI
[2]  
BAILEY PL, 1987, ANESTH ANALG, V66, P1109
[3]  
BEAVER WT, 1978, J PHARMACOL EXP THER, V204, P487
[4]   Generous use of opioids is advantageous for infants and children - Pro [J].
Becke, Karin .
ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 2010, 45 (7-8) :470-472
[5]   PROPOFOL AND SPONTANEOUS MOVEMENTS - AN EEG STUDY [J].
BORGEAT, A ;
DESSIBOURG, C ;
POPOVIC, V ;
MEIER, D ;
BLANCHARD, M ;
SCHWANDER, D .
ANESTHESIOLOGY, 1991, 74 (01) :24-27
[6]   THE EFFECT OF NALBUPHINE AND DROPERIDOL ON SPONTANEOUS MOVEMENTS DURING INDUCTION OF ANESTHESIA WITH PROPOFOL IN CHILDREN [J].
BORGEAT, A ;
FUCHS, T ;
WILDERSMITH, O ;
TASSONYI, E .
JOURNAL OF CLINICAL ANESTHESIA, 1993, 5 (01) :12-15
[7]   SPONTANEOUS EXCITATORY MOVEMENTS DURING RECOVERY FROM PROPOFOL ANESTHESIA IN AN INFANT - EEG EVALUATION [J].
BORGEAT, A ;
WILDERSMITH, OHG ;
DESPLAND, PA ;
RAVUSSIN, P .
BRITISH JOURNAL OF ANAESTHESIA, 1993, 70 (04) :459-461
[8]   A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department [J].
Borland, Meredith ;
Jacobs, Ian ;
King, Barbara ;
O'Brien, Debra .
ANNALS OF EMERGENCY MEDICINE, 2007, 49 (03) :335-340
[9]   Population pharmacokinetics of nalbuphine after surgery in children [J].
Bressolle, F. ;
Khier, S. ;
Rochette, A. ;
Kinowski, J. M. ;
Dadure, C. ;
Capdevila, X. .
BRITISH JOURNAL OF ANAESTHESIA, 2011, 106 (04) :558-565
[10]  
BUTTNER W, 1990, ANAESTHESIST, V39, P258
123456789