Contribution of Monovalent (Na+ and K+) and Divalent (Ca2+) Ions to the Mechanisms of Synaptic Plasticity

被引：1

作者：

Smolyaninova, L., V ^{[1
]}

Shiyan, A. A. ^{[1
]}

Maksimov, G., V ^{[1
]}

Orlov, S. N. ^{[1
]}

机构：

[1] Moscow Lomonosov State Univ, Fac Biol, Moscow 119992, Russia

来源：

BIOLOGICHESKIE MEMBRANY | 2020年 / 37卷 / 06期

关键词：

sodium; potassium; calcium; synaptic plasticity; long-term potentiation; long-term depression; gene expression; LONG-TERM POTENTIATION; INOSITOL TRISPHOSPHATE RECEPTORS; ACTIVATED POTASSIUM CHANNELS; C-FOS EXPRESSION; PROTEIN-KINASE-C; PLASMA-MEMBRANE; NMDA RECEPTOR; CALCIUM-CHANNEL; CEREBELLAR PURKINJE; RYANODINE RECEPTOR;

D O I：

10.31857/S0233475520060067

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The review surveys the involvement of ions (Na+, K+, and Ca2+) in the synaptic plasticity processes during long-term potentiation (LTP) and long-term depression (LTD) in a postsynaptic neuron. It is suggested that the main participants are AMPA and NMMDA receptors; voltage-dependent Na+, K+, and Ca2+ channels; Ca2+- and Na+-activated K+ channels; ATP-sensitive K+ channels, and Ca2+ channels of the endoplasmic reticulum. Their molecular characteristics and the role in LTP and LTD are reviewed. The role of changes in the intracellular [Na+](i)/[K+](i) ratio and Ca2+-dependent mechanisms in signal generation up to the level of gene expression is considered for the first time. We think that additional research is needed to identify the subset of neuronal genes, whose differential expression contributes to synaptic plasticity via the [Na+](i)/[K+](i)-sensitive, Ca2+-independent excitation transcription coupling mechanism.

引用

页码：403 / 425

页数：23

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