Copper-Catalyzed Three-Component Carboamination of Arynes: Expeditious Synthesis of o-Alkynyl Anilines and o-Benzoxazolyl Anilines

被引：18
|
作者：
Niu, Sheng-Li [1 ]
Hu, Jiangtao [1 ]
He, Kuicheng [1 ]
Chen, Ying-Chun [1 ]
Xiao, Qing [1 ]
机构：
[1] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 11期
关键词：
TRANSITION-METAL-FREE; C-H AMINATION; ELECTROPHILIC AMINATION; OXIDATIVE ANNULATION; EMPLOYING ARYNES; ARYL HALIDES; CARBON; ARENES; CYCLIZATION; ACTIVATION;
D O I：
10.1021/acs.orglett.9b01427
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed three-component reaction of in situ formed arynes, terminal alkynes, and O-benzoylhydroxylamines has been developed. By adjusting reaction conditions, the nucleophiles in this transformation can be extended from terminal alkynes to benzoxazoles. These procedures provide a modular and facile approach to o-alkynyl anilines and o-benzoxazolyl anilines from easily available substrates in only one step.
引用
收藏
页码：4250 / 4254
页数：5
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