Ligand-Promoted Borylation of C(sp3)-H Bonds with Palladium(II) Catalysts

被引：115

作者：

He, Jian ^{[1
]}

Jiang, Heng ^{[1
]}

Takise, Ryosuke ^{[1
]}

Zhu, Ru-Yi ^{[1
]}

Chen, Gang ^{[1
]}

Dai, Hui-Xiong ^{[1
]}

Dhar, T. G. Murali ^{[2
]}

Shi, Jun ^{[3
]}

Zhang, Hao ^{[3
]}

Cheng, Peter T. W. ^{[3
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Bristol Myers Squibb Co, Discovery Chem, Princeton, NJ 08543 USA

[3] Bristol Myers Squibb Co, Discovery Chem, Pennington, NJ 08534 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 02期

基金：

美国国家科学基金会;

关键词：

C-H BORYLATION; CROSS-COUPLING REACTIONS; ARYL CHLORIDES; ROOM-TEMPERATURE; AROMATIC BORYLATION; ARENES; FUNCTIONALIZATION; ESTERS; ACIDS; DERIVATIVES;

D O I：

10.1002/anie.201509996

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A quinoline-based ligand effectively promotes the palladium-catalyzed borylation of C(sp(3))-H bonds. Primary beta-C(sp(3))-H bonds in carboxylic acid derivatives as well as secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)-and rhodium(I)-catalyzed C-H borylation reactions in terms of scope and operational conditions.

引用

页码：785 / 789

页数：5

共 68 条

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