Inflammatory bowel disease in pediatric and adolescent patients: A biomolecular and histopathological review

被引：30

作者：

Rigoli, Luciana ^{[1
]}

Caruso, Rosario Alberto ^{[2
]}

机构：

[1] Univ Messina, Dept Pediat, I-98125 Messina, Italy

[2] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 30期

关键词：

Pediatric inflammatory bowel disease; Crohn's disease; Ulcerative disease; Histopathology; Molecular biology; GENOME-WIDE ASSOCIATION; ONSET CROHNS-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; ALPHA-DEFENSIN EXPRESSION; ULCERATIVE-COLITIS; INDETERMINATE COLITIS; SUSCEPTIBILITY LOCI; CARD15; MUTATIONS; PHENOTYPIC CHARACTERISTICS; INTERLEUKIN-10; RECEPTOR;

D O I：

10.3748/wjg.v20.i30.10262

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory bowel disease (IBD) with both overlapping and distinct clinical, pathological and biomolecular features. It has been suggested that pediatric IBD is a distinct disease entity, with probably different disease subtypes. The aim of this study is to review and summarize the evolution of the current concept of pediatric IBD. The results of this review reinforce the idea that pediatric CD and UC may be further classified in various clinicopathologic entities. For clinicians and pathologists convenience, practical algorithms for the distinction of the various subphenotypes of pediatric IBD are also provided. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：10262 / 10278

页数：17

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