Bacterial multidrug transport through the lens of the major facilitator superfamily

被引：103

作者：

Fluman, Nir ^{[1
]}

Bibi, Eitan ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2009年 / 1794卷 / 05期

基金：

以色列科学基金会;

关键词：

Secondary transport; Multidrug transport; Multidrug resistance; MDR; Major facilitator superfamily; MFS; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; EFFLUX PUMP; BACILLUS-SUBTILIS; SIMULTANEOUS BINDING; RESISTANCE PROTEIN; NUCLEOTIDE-SEQUENCE; CRYSTAL-STRUCTURES; NA+/H+ ANTIPORTER; LACTOSE PERMEASE;

D O I：

10.1016/j.bbapap.2008.11.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells resistant to multiple drugs. These transporters are found in many different families of transport proteins, of which the largest is the major facilitator superfamily. Multidrug transporters from this family are highly represented in bacteria and studies of them have provided important insight into the mechanism underlying multidrug transport. This review summarizes the work carried out on these interesting proteins and underscores the differences and similarities to other transport systems. (C) 2008 Elsevier B.V. All rights reserved.

引用

收藏

页码：738 / 747

页数：10

相关论文

共 111 条

[41] SURFACE GLYCOPROTEIN MODULATING DRUG PERMEABILITY IN CHINESE-HAMSTER OVARY CELL MUTANTS [J].

JULIANO, RL ;

LING, V .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 455 (01) :152-162

[42] Effect of promoter region mutations and mgrA overexpression on transcription of norA, which encodes a Staphylococcus aureus multidrug efflux transporter [J].

Kaatz, GW ;

Thyagarajan, RV ;

Seo, SM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) :161-169

[43] Site-directed alkylation and the alternating access model for LacY [J].

Kaback, H. Ronald ;

Dunten, R. ;

Frillingos, S. ;

Venkatesan, P. ;

Kwaw, I. ;

Zhang, W. ;

Ermolova, Natalia .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (02) :491-494

[44] Roles of conserved arginine residues in the metal-tetracycline/H+ antiporter of Escherichia coli [J].

Kimura, T ;

Nakatani, N ;

Kawabe, T ;

Yamaguchi, A .

BIOCHEMISTRY, 1998, 37 (16) :5475-5480

[45] Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr [J].

Klyachko, KA ;

Schuldiner, S ;

Neyfakh, AA .

JOURNAL OF BACTERIOLOGY, 1997, 179 (07) :2189-2193

[46] Microbial transport: Adaptations to natural environments [J].

Konings, Wil N. .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2006, 90 (04) :325-342

[47] Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study [J].

Krulwich, TA ;

Lewinson, O ;

Padan, E ;

Bibi, E .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (07) :566-572

[48] Bacterial resistance to antibiotics: Active efflux and reduced uptake [J].

Kumar, A ;

Schweizer, HP .

ADVANCED DRUG DELIVERY REVIEWS, 2005, 57 (10) :1486-1513

[49] Ins and Outs of Major Facilitator Superfamily, Antiporters [J].

Law, Christopher J. ;

Maloney, Peter C. ;

Wang, Da-Neng .

ANNUAL REVIEW OF MICROBIOLOGY, 2008, 62 :289-305

[50] Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT [J].

Law, Christopher J. ;

Almqvist, Jonas ;

Bernstein, Adam ;

Goetz, Regina M. ;

Huang, Yafei ;

Soudant, Celine ;

Laaksonen, Aatto ;

Hovmoller, Sven ;

Wang, Da-Neng .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 378 (04) :828-839

← 1 2 3 4 5 6 7 8 9 10 →