Synthesis and biological evaluation of abietic acid derivatives

被引：75
作者：
Gonzalez, Miguel A. [1 ]
Correa-Royero, Julieth [2 ]
Agudelo, Lee [2 ]
Mesa, Ana [2 ]
Betancur-Galvis, Liliana [2 ]
机构：
[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain
[2] Univ Antioquia, Grp Infecc & Canc, Medellin 1226, Colombia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 06期
关键词：
Abietic acid; Cytotoxicity; Antimycotic activity; Antiviral activity; CYTOTOXIC ACTIVITY; DITERPENES;
D O I：
10.1016/j.ejmech.2009.01.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at 08 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2468 / 2472
页数：5
相关论文
共 20 条
  • [11] Lin Ch.-H., 2006, US Patent, Patent No. [7015248 B2, 7015248]
  • [12] Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stems
    Martin, D
    Tholl, D
    Gershenzon, J
    Bohlmann, J
    [J]. PLANT PHYSIOLOGY, 2002, 129 (03) : 1003 - 1018
  • [13] *NAT COMM CLIN LAB, 2002, REF METH BROTH DIL A
  • [14] Cytotoxic activity screening of some indigenous Thai plants
    Prayong, P.
    Barusrux, S.
    Weerapreeyakul, N.
    [J]. FITOTERAPIA, 2008, 79 (7-8) : 598 - 601
  • [15] ABIETANE ACIDS - SOURCES, BIOLOGICAL-ACTIVITIES, AND THERAPEUTIC USES
    SANFELICIANO, A
    GORDALIZA, M
    SALINERO, MA
    DELCORRAL, JMM
    [J]. PLANTA MEDICA, 1993, 59 (06) : 485 - 490
  • [16] PHYTOALEXIN-LIKE ACTIVITY OF ABIETIC ACID AND ITS DERIVATIVES
    SPESSARD, GO
    MATTHEWS, DR
    NELSON, MD
    RAJTORA, TC
    FOSSUM, MJ
    GIANNINI, JL
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1995, 43 (06) : 1690 - 1694
  • [17] Abietic acid activates peroxisome proliferator-activated receptor-γ (PPARγ) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism
    Takahashi, N
    Kawada, T
    Goto, T
    Kim, CS
    Taimatsu, A
    Egawa, K
    Yamamoto, T
    Jisaka, M
    Nishimura, K
    Yokota, K
    Yu, R
    Fushiki, T
    [J]. FEBS LETTERS, 2003, 550 (1-3) : 190 - 194
  • [18] Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis
    Talevi, Alan
    Cravero, Mariana Sella
    Castro, Eduardo A.
    Bruno-Blanch, Luis E.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (06) : 1684 - 1690
  • [19] Abietic acid inhibits lipoxygenase activity
    Ulusu, NN
    Ercil, D
    Sakar, MK
    Tezcan, EF
    [J]. PHYTOTHERAPY RESEARCH, 2002, 16 (01) : 88 - 90
  • [20] SCREENING OF 100 RWANDESE MEDICINAL-PLANTS FOR ANTIMICROBIAL AND ANTIVIRAL PROPERTIES
    VLIETINCK, AJ
    VANHOOF, L
    TOTTE, J
    LASURE, A
    VANDENBERGHE, D
    RWANGABO, PC
    MVUKIYUMWAMI, J
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1995, 46 (01) : 31 - 47
12