Synthesis and biological evaluation of abietic acid derivatives

被引：75
作者：
Gonzalez, Miguel A. [1 ]
Correa-Royero, Julieth [2 ]
Agudelo, Lee [2 ]
Mesa, Ana [2 ]
Betancur-Galvis, Liliana [2 ]
机构：
[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain
[2] Univ Antioquia, Grp Infecc & Canc, Medellin 1226, Colombia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 06期
关键词：
Abietic acid; Cytotoxicity; Antimycotic activity; Antiviral activity; CYTOTOXIC ACTIVITY; DITERPENES;
D O I：
10.1016/j.ejmech.2009.01.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at 08 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds. (C) 2009 Elsevier Masson SAS. All rights reserved.
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收藏
页码：2468 / 2472
页数：5
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