Selective autophagy of intracellular organelles: recent research advances

被引：398

作者：

Li, Wen ^{[1
,2
,3
]}

He, Pengcheng ^{[4
,5
]}

Huang, Yuge ^{[3
]}

Li, Yi-Fang ^{[2
]}

Lu, Jiahong ^{[6
]}

Li, Min ^{[7
]}

Kurihara, Hiroshi ^{[2
]}

Luo, Zhuo ^{[2
]}

Meng, Tian ^{[1
,8
]}

Onishi, Mashun ^{[9
]}

Ma, Changle ^{[10
]}

Jiang, Lei ^{[5
]}

Hu, Yongquan ^{[1
,8
]}

Gong, Qing ^{[11
]}

Zhu, Dongxing ^{[12
]}

Xu, Yiming ^{[13
]}

Liu, Rong ^{[14
,15
]}

Liu, Lei ^{[16
]}

Yi, Cong ^{[17
,18
]}

Zhu, Yushan ^{[19
]}

Ma, Ningfang ^{[1
,8
]}

Okamoto, Koji ^{[9
]}

Xie, Zhiping ^{[20
,21
]}

Liu, Jinbao ^{[1
]}

He, Rong-Rong ^{[2
]}

Feng, Du ^{[1
,8
]}

机构：

[1] Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou Municipal & Guangdong Prov Key Lab Prot, State Key Lab Resp Dis, Guangzhou 511436, Peoples R China

[2] Jinan Univ, Coll Pharm, Chinese Minist Educ MOE, Int Cooperat Lab Tradit Chinese Med Modernizat &, Guangzhou 510632, Peoples R China

[3] Guangdong Med Univ, Dept Pediat, Affiliated Hosp, Zhanjiang 524001, Peoples R China

[4] Guangdong Gen Hosp, Dept Cardiol, Nanhai Hosp, Foshan, Peoples R China

[5] Guangdong Gen Hosp, Guangdong Acad Med Sci, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Dept Cardiol,Guangdong Cardiovasc Inst, Guangzhou, Peoples R China

[6] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[7] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

[8] Guangzhou Med Univ, Affiliated Canc Hosp, Guangzhou 510095, Peoples R China

[9] Osaka Univ, Grad Sch Frontier Biosci, 1-3 Yamadaoka, Suita, Osaka 5650871, Japan

[10] Shandong Normal Univ, Coll Life Sci, Shandong Prov Key Lab Plant Stress, Wenhua East Rd 88, Jinan 250014, Peoples R China

[11] Guangzhou Med Univ, GMU GIBH Joint Sch Life Sci, Dept Biochem & Mol Biol, Guangzhou 511436, Peoples R China

[12] Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou Inst Cardiovasc Dis, Affiliated Hosp 2,Key Lab Cardiovasc Dis, Guangzhou 511436, Peoples R China

[13] Guangzhou Med Univ, Qingyuan Peoples Hosp, Affiliated Hosp 6, Sch Basic Med Sci, Guangzhou, Guangdong, Peoples R China

[14] Nanjing Agr Univ, Coll Food Sci & Technol, Dept Food Sci, Nanjing 210095, Jiangsu, Peoples R China

[15] Natl Ctr Int Res Anim Gut Nutr, Nanjing 210095, Jiangsu, Peoples R China

[16] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China

[17] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China

[18] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310058, Peoples R China

[19] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

[20] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai, Peoples R China

[21] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Res Lab Metab & Dev Sci, Shanghai, Peoples R China

来源：

THERANOSTICS | 2021年 / 11卷 / 01期

关键词：

selective autophagy; autophagy receptor; mitophagy; ER-phagy; proteaphagy; ribophagy; pexophagy; lipophagy; lysophagy; nucleophagy; ENDOPLASMIC-RETICULUM TURNOVER; REGULATES MITOCHONDRIAL DYNAMICS; CERAMIDE TARGETS AUTOPHAGOSOMES; PARKIN-MEDIATED MITOPHAGY; ER-PHAGY; PIECEMEAL MICROAUTOPHAGY; CARGO RECOGNITION; LIPID-METABOLISM; OUTER-MEMBRANE; HOPS COMPLEX;

D O I：

10.7150/thno.49860

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and invading pathogens via the lysosomal system (the vacuole in plants and yeast). Autophagy is generally induced by stress, such as oxygen-, energy- or amino acid-deprivation, irradiation, drugs, etc. In addition to non-selective bulk degradation, autophagy also occurs in a selective manner, recycling specific organelles, such as mitochondria, peroxisomes, ribosomes, endoplasmic reticulum (ER), lysosomes, nuclei, proteasomes and lipid droplets (LDs). This capability makes selective autophagy a major process in maintaining cellular homeostasis. The dysfunction of selective autophagy is implicated in neurodegenerative diseases (NDDs), tumorigenesis, metabolic disorders, heart failure, etc. Considering the importance of selective autophagy in cell biology, we systemically review the recent advances in our understanding of this process and its regulatory mechanisms. We emphasize the `cargo-ligand-receptor' model in selective autophagy for specific organelles or cellular components in yeast and mammals, with a focus on mitophagy and ER-phagy, which are finely described as types of selective autophagy. Additionally, we highlight unanswered questions in the field, helping readers focus on the research blind spots that need to be broken.

引用

页码：222 / 256

页数：35

共 394 条

[1] SNARE priming is essential for maturation of autophagosomes but not for their formation [J].