Modulation of apoptosis by HIV protease inhibitors

被引：21
作者：
Phenix, BN
Cooper, C
Owen, C
Badley, AD
机构：
[1] Mayo Clin & Mayo Fdn, Dept Med, Div Infect Dis, Rochester, MN 55905 USA
[2] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
[3] Ottawa Hlth Res Inst, Ottawa, ON, Canada
[4] Ottawa Hosp, Div Infect Dis, Ottawa, ON, Canada
[5] Ottawa Hosp, Dept Med, Ottawa, ON, Canada
来源：
APOPTOSIS | 2002年 / 7卷 / 04期
基金：
加拿大健康研究院;
关键词：
apoptosis; CD4 T cell; HIV; immunity; protease inhibitor;
D O I：
10.1023/A:1016168411221
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Advances in treatment have transformed the Human Immunodeficiency Virus (HIV) infection from a progressive and ultimately fatal disease to one that can be managed effectively by chronic suppressive antiretroviral therapy. The drugs now used to treat HIV infection not only inhibit viral replication but also have effects on cellular metabolism and homeostasis. Of particular interest to cellular immunologists, members of the HIV Protease Inhibitor (PI) class of antiretroviral agents possess intrinsic immunomodulatory and antiapoptotic properties. This review focuses on the development and use of PI together with their impact on HIV disease, immunity, and apoptosis.
引用
收藏
页码：295 / 312
页数：18
相关论文
共 210 条
[51]   AMYOTROPHIC-LATERAL-SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE-DISMUTASE [J].
DENG, HX ;
HENTATI, A ;
TAINER, JA ;
IQBAL, Z ;
CAYABYAB, A ;
HUNG, WY ;
GETZOFF, ED ;
HU, P ;
HERZFELDT, B ;
ROOS, RP ;
WARNER, C ;
DENG, G ;
SORIANO, E ;
SMYTH, C ;
PARGE, HE ;
AHMED, A ;
ROSES, AD ;
HALLEWELL, RA ;
PERICAKVANCE, MA ;
SIDDIQUE, T .
SCIENCE, 1993, 261 (5124) :1047-1051
[52]  
DEWAZIERS I, 1990, J PHARMACOL EXP THER, V253, P387
[53]   Spontaneous apoptosis and highly active antiretroviral therapy (HAART) [J].
Dieye, TN ;
Van Vooren, JP ;
Delforge, ML ;
Liesnard, C ;
Devleeschouwer, M ;
Farber, CM .
BIOMEDICINE & PHARMACOTHERAPY, 2000, 54 (01) :16-20
[54]   Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number [J].
Dockrell, DH ;
Badley, AD ;
Algeciras-Schimnich, A ;
Simpson, M ;
Schut, R ;
Lynch, DH ;
Paya, CV .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (17) :1509-1518
[55]   Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy [J].
Domingo, P ;
Matias-Guiu, X ;
Pujol, RM ;
Francia, E ;
Lagarda, E ;
Sambeat, MA ;
Vázquez, G .
AIDS, 1999, 13 (16) :2261-2267
[56]   Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy [J].
Domingo, P ;
Matías-Guiu, X ;
Pujol, RM ;
Domingo, JC ;
Arroyo, JA ;
Sambeat, MA ;
Vázquez, G .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (09) :1197-1201
[57]   Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors [J].
Dowell, P ;
Flexner, C ;
Kwiterovich, PO ;
Lanes, MD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (52) :41325-41332
[58]   INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE INVITRO - RATIONAL DESIGN OF SUBSTRATE-ANALOG INHIBITORS [J].
DREYER, GB ;
METCALF, BW ;
TOMASZEK, TA ;
CARR, TJ ;
CHANDLER, AC ;
HYLAND, L ;
FAKHOURY, SA ;
MAGAARD, VW ;
MOORE, ML ;
STRICKLER, JE ;
DEBOUCK, C ;
MEEK, TD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9752-9756
[59]   The Fas/FasL system and T cell apoptosis in HIV-1-infected lymphoid tissue during highly active antiretroviral therapy [J].
Dyrhol-Riise, AM ;
Stent, G ;
Rosok, BI ;
Voltersvik, P ;
Olofsson, J ;
Åsjö, B .
CLINICAL IMMUNOLOGY, 2001, 101 (02) :169-179
[60]   T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: Impact of highly active antiretroviral therapy [J].
Dyrhol-Riise, AM ;
Ohlsson, M ;
Skarstein, K ;
Nygaard, SJT ;
Olofsson, J ;
Jonsson, R ;
Åsjö, B .
CLINICAL IMMUNOLOGY, 2001, 101 (02) :180-191
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