Invasive fungal diseases during first induction chemotherapy affect complete remission achievement and long-term survival of patients with acute myeloid leukemia

被引：33

作者：

Girmenia, Corrado ^{[1
]}

Micozzi, Alessandra ^{[1
]}

Piciocchi, Alfonso ^{[2
]}

Gentile, Giuseppe ^{[1
]}

Di Caprio, Luigi ^{[3
]}

Nasso, Daniela ^{[3
]}

Minotti, Clara ^{[1
]}

Capria, Saveria ^{[1
]}

Cartoni, Claudio ^{[1
]}

Alimena, Giuliana ^{[1
]}

Meloni, Giovanna ^{[1
]}

Amadori, Sergio ^{[3
]}

Foa, Robin ^{[1
]}

Venditti, Adriano ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Azienda Policlin Umberto 1, Dipartimento Ematol Oncol Anat Patol & Med Rigene, I-00161 Rome, Italy

[2] Fdn GIMEMA Grp Italiano Malattie EMatol Adulto, Rome, Italy

[3] Univ Tor Vergata, Dipartimento Biomed & Prevenz, Rome, Italy

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 04期

关键词：

Invasive fungal disease; Aspergillosis; Acute myeloid leukemia; Complete remission; Survival; NEUTROPENIC PATIENTS; SINGLE-CENTER; PHASE-II; ASPERGILLOSIS; PROPHYLAXIS; MANAGEMENT; DIAGNOSIS; UPDATE; RECOMMENDATIONS; AML-13;

D O I：

10.1016/j.leukres.2014.01.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% Cl 1.71-9.81, p <0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% Cl 1.20-2.88, p = 0.005) were independent factors associated to OS at 3 years. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：469 / 474

页数：6

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