How to Manage Patients with Differentiated Thyroid Cancer and a Rising Serum Thyroglobulin Level

被引：9

作者：

Elisei, Rossella ^{[1
]}

Agate, Laura ^{[1
]}

Viola, David ^{[1
]}

Matrone, Antonio ^{[1
]}

Biagini, Agnese ^{[1
]}

Molinaro, Eleonora ^{[1
]}

机构：

[1] Univ Pisa, WHO Collaborating Ctr Study & Treatment Thyroid D, Dept Clin & Expt Med, Endocrinol Unit, I-56124 Pisa, Italy

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 02期

关键词：

Differentiated thyroid carcinoma; Thyroglobulin; Recombinant human TSH; Thyroid hormones; 131-iodine; RECOMBINANT HUMAN TSH; LOW-RISK PATIENTS; WHOLE-BODY SCANS; FOLLOW-UP; STIMULATED THYROGLOBULIN; REMNANT ABLATION; THYROTROPIN SUPPRESSION; ELEVATED THYROGLOBULIN; INITIAL TREATMENT; CENTER EXPERIENCE;

D O I：

10.1016/j.ecl.2014.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum thyroglobulin (sTg) is the marker for monitoring persistence/recurrence of differentiated thyroid cancer, in patients without sTg antibodies. Patients with undetectable basal sTg or peak sTg <2 ng/mL are cured with low risk to recur. Newly detectable level of sTg indicates the recurrence. The significance of increasing sTg in patients treated with emithyroidectomy or total-thyroidectomy but not ablated with radioiodine is undefined. A doubling time <1 year may be a poor prognostic factor, but this is more relevant in cases with high levels of sTg. Because of its sensitivity, neck ultrasound should be performed at any visit, especially when an increased sTg is seen.

引用

页码：331 / +

页数：15

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