CD11b+ Myeloid Cells Are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation

被引：103

作者：

Medoff, Benjamin D. ^{[1
,2
,3
,4
]}

Seung, Edward ^{[1
,2
]}

Hong, Sandra ^{[1
,2
]}

Thomas, Seddon Y. ^{[1
,2
]}

Sandall, Barry P. ^{[1
,2
,3
,4
]}

Duffield, Jeremy S. ^{[5
,6
,7
]}

Kuperman, Douglas A. ^{[8
]}

Erle, David J. ^{[9
,10
]}

Luster, Andrew D. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Div Rheumatol Allergy & Immunol, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Pulm & Crit Care Unit, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA 02114 USA

[5] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Boston, MA 02115 USA

[8] Northwestern Univ, Feinberg Sch Med, Div Allergy Immunol, Chicago, IL 60611 USA

[9] Univ Calif San Francisco, Lung Biol Ctr, Dept Med, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[10] Univ Calif San Francisco, Program Immunol, San Francisco, CA 94143 USA

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ACTIVATION-REGULATED CHEMOKINE; THYMIC STROMAL LYMPHOPOIETIN; EPITHELIAL-CELLS; LUNG INFLAMMATION; DENDRITIC CELL; EXPERIMENTAL ASTHMA; EOTAXIN EXPRESSION; SIGNAL TRANSDUCER; MUCUS PRODUCTION; TYPE-2; IMMUNITY;

D O I：

10.4049/jimmunol.182.1.623

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

STAT6-mediated chemokine production in the lung is required for Th2 lymphocyte and eosinophil homing into the airways in allergic pulmonary inflammation, and thus is a potential therapeutic target in asthma. However, the critical cellular source of STAT6-mediated chemokine production has not been defined. In this study, we demonstrate that STAT6 in bone marrow-derived myeloid cells was sufficient for the production of CCL17, CCL22, CCL11, and CCL24 and for Th2 lymphocyte and eosinophil recruitment into the allergic airway. In contrast, STAT6 in airway-lining cells did not mediate chemokine production or support cellular recruitment. Selective depletion of CD11b(+) myeloid cells in the lung identified these cells as the critical cellular source for the chemokines CCL17 and CCL22. These data reveal that CD11b(+) myeloid cells in the lung help orchestrate the adaptive immune response in asthma, in part, through the production of STAT6-inducible chemokines and the recruitment of Th2 lymphocytes into the airway. The Journal of Immunology, 2009, 182: 623-635.

引用

页码：623 / 635

页数：13

共 66 条

[1]

Andrew DP, 1998, J IMMUNOL, V161, P5027

[2] Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation [J].