Transdermal treatment of the surgical and burned wound skin via phytochemical-capped gold nanoparticles

被引：37

作者：

Lee, Jaewook ^{[1
,3
]}

Kim, JiEun ^{[2
]}

Go, Jun ^{[2
]}

Lee, Jong Ho ^{[1
]}

Han, Dong-Wook ^{[1
]}

Hwang, DaeYoun ^{[2
]}

Lee, Jaebeom ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Cognomechatron Engn, Pusan 609735, South Korea

[2] Pusan Natl Univ, Dept Biomat Sci, Coll Nat Resources & Life Sci, Life & Ind Convergence Res Inst, Miryang 627706, South Korea

[3] Univ Calgary, Dept Mech & Mfg Engn, Calgary, AB T2N 1N4, Canada

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2015年 / 135卷

基金：

新加坡国家研究基金会;

关键词：

Skin regeneration; Surgically damaged skin repair; Burned skin-healing; Phytochemicals; Au nanoparticle; Metalloproteinase inhibition; ENDOTHELIAL GROWTH-FACTOR; IN-VIVO; TGF-BETA; EPIDERMAL REGENERATION; VESSEL REGENERATION; STEM-CELLS; MATRIX; DELIVERY; KERATINOCYTES; MODEL;

D O I：

10.1016/j.colsurfb.2015.07.058

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The biological activities and therapeutic potential of phytochemical-decorated Au nanoparticles (Phyto-AuNPs) were investigated through the treatment of Phyto-AuNPs on the dorsal skin of rats via transdermal drug delivery process in order to regenerate surgical wounded and burned skin. Two different Phyto-AuNPs were applied to the dorsal skin: gallic acid-isoflavone - covered AuNPs (GI-AuNPs) and protocatechuic acid-isoflavone - covered AuNPs (PI-AuNPs). From the biological activity monitoring, it has been resulted that 5-fold thicker epidermis (ER), 50% reduction of metalloproteinase-1 (MMP-1) level, 3-fold higher superoxide dismutase (SOD) activity were obtained in the Phyto-AuNP-treated group, compared with a vehicle group (deionized water (DI-water) treatment). Moreover, the Phyto-AuNPs treatment on the surgical and burn damaged Sprague-Dawley (SD) rats induced higher expression of vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2). It would be plausible that antioxidant property of Phyto-AuNPs assist the acceleration and activation of biomolecules in the healing mechanism, where Phyto-AuNPs can be potential candidates for skin regeneration and wound healing. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：166 / 174

页数：9

共 63 条

[1] Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction [J].