Metal-Free Azaphosphaannulation of Phosphonamides through Intramolecular Oxidative C-N Bond Formation

被引：31
|
作者：
Kim, Yea Rin [1 ]
Cho, Seungyoon [1 ]
Lee, Phil Ho [1 ]
机构：
[1] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
PALLADIUM(II)-CATALYZED ORTHO-ARYLATION; CATALYZED ORTHO-ALKENYLATION; ARYL HYDROGEN PHOSPHATES; H BONDS; ORTHO-OLEFINATION; DIRECTING GROUP; ACID; ACTIVATION; PHOSPHAISOCOUMARINS; ALKYNYLATION;
D O I：
10.1021/ol501207w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report an efficient metal-free azaphosphaannulation of a myriad of phosphonamides through intramolecular oxidative C-N bond formation using Phl(OAc)(2) and iodine in acetonitrile under air, thus leading to the formation of benzazaphosphol-3-one 1-oxides, which are novel phosphorus heterocyclic privileged structures.
引用
收藏
页码：3098 / 3101
页数：4
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