Mitochondrial biogenesis and dynamics in the developing and diseased heart

被引：385
作者：
Dorn, Gerald W., II [1 ]
Vega, Rick B. [2 ]
Kelly, Daniel P. [2 ]
机构：
[1] Washington Univ, Ctr Pharmacogenom, St Louis, MO 63110 USA
[2] Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL 32827 USA
来源：
GENES & DEVELOPMENT | 2015年 / 29卷 / 19期
基金：
美国国家卫生研究院;
关键词：
mitochondria; biogenesis; mitophagy; mitochondrial dynamics; PROLIFERATOR-ACTIVATED RECEPTOR; FATTY-ACID OXIDATION; PALMITOYLTRANSFERASE I GENE; NUCLEAR RESPIRATORY FACTORS; ALPHA PPAR-ALPHA; SKELETAL-MUSCLE; ERR-ALPHA; MICE LACKING; PERIIMPLANTATION LETHALITY; GAMMA COACTIVATOR-1-ALPHA;
D O I：
10.1101/gad.269894.115
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.
引用
收藏
页码：1981 / 1991
页数：11
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