Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia

被引：22
作者：
Baurska, Hanna [1 ]
Kielbinski, Marek [2 ]
Biecek, Przemyslaw [3 ]
Haus, Olga [4 ]
Jazwiec, Bozena [2 ]
Kutner, Andrzej [5 ]
Marcinkowska, Ewa [1 ]
机构：
[1] Univ Wroclaw, Fac Biotechnol, PL-50383 Wroclaw, Poland
[2] Wroclaw Med Univ, Det Hematol Blood Neoplasms & Bone Marrow Transpl, PL-50367 Wroclaw, Poland
[3] Univ Warsaw, Inst Appl Math & Mech, Warsaw, Poland
[4] Nicolaus Copernicus Univ, Coll Med, Dept Clin Genet, PL-85094 Bydgoszcz, Poland
[5] Pharmaceut Res Inst, PL-01793 Warsaw, Poland
来源：
LEUKEMIA RESEARCH | 2014年 / 38卷 / 05期
关键词：
Acute myeloid leukemia; Blasts; Differentiation; 1:25 dihydroxyvitamin D3; Vitamin D analogs; Flow cytometry; Statistical analysis; Personalized anticancer therapy; ANTIPROLIFERATIVE ACTIVITY; AML; ASSOCIATION; INDUCTION; THERAPY;
D O I：
10.1016/j.leukres.2014.03.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The differentiation-inducing potential of side-chain modified analogs of vitamins D, compared to the reference compound, 1,25-dihydroxyvitamin D-3, was studied in blast cells from patients with acute myeloid leukemia and in cell lines. Analogs PRI-1906 and PRI-1907 showed increased cell-differentiation activities, PRI-1907 even at a very low concentration. Our study revealed a high variability of individual patients' blasts in their susceptibility to vitamin D analogs. The blasts of the patients with normal karyotype and with mutated NPM1 reacted to analogs with stronger differentiation than the blasts of the remaining patients, while the blasts with mutated FLT3 receptor reacted with weaker differentiation than the remaining blasts. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：638 / 647
页数：10
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