Deracemization of (+/-)-2,2-disubstituted epoxides via enantioconvergent chemoenzymatic hydrolysis using Nocardia EH1 epoxide hydrolase and sulfuric acid

被引：29

作者：

Orru, RVA ^{[1
]}

Kroutil, W ^{[1
]}

Faber, K ^{[1
]}

机构：

[1] GRAZ UNIV TECHNOL,INST ORGAN CHEM,A-8010 GRAZ,AUSTRIA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)00201-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Substituted (S)-1,2-diols were prepared in a one-pot procedure with >90% ee and >90% isolated yield via deracemization of (+/-)-2,2-disubstituted oxiranes through sequential (i) biocatalytic asymmetric hydrolysis using Nocardia EH1 epoxide hydrolase and (ii) acid catalyzed hydrolysis of the remaining oxirane enantiomer. (C) 1997 Elsevier Science Ltd.

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页码：1753 / 1754

页数：2

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