The Emerging Role of Functional MRI for Evaluating Fetal Brain Activity

Although functional magnetic resonance imaging is a technique that is widely used in adult populations, its use within a fetal environment has been extremely limited. Problems associated with movement and technical scanning issues have limited its effectiveness in providing reliable and spatially accurate details of fetal brain activity. However, initial research has indicated that it is a viable tool for assessing functional maturation in the fetus, and recent advances in echo-planar imaging sequences on the abdomen at 3-T provide the potential for more reliable activation detection and higher resolution spatial information. If the technique can be further developed such that a similar reliability in activity patterns is observed as in conventional functional MRI, then fetal functional MRI could offer a useful contribution at a clinical level as well as at a research one in the assessment of brain development and maturation. © 2009 Elsevier Inc. All rights reserved.