A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene

被引：11

作者：

Acutis, P. L. ^{[1
]}

Martucci, F. ^{[1
]}

Mazza, M. ^{[1
]}

Peletto, S. ^{[1
]}

Iulini, B. ^{[1
]}

Corona, C. ^{[1
]}

Bozzetta, E. ^{[1
]}

Casalone, C. ^{[1
]}

Caramelli, M. ^{[1
]}

机构：

[1] CEA, IZS Piemonte, I-10154 Turin, Italy

来源：

ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 09期

关键词：

D O I：

10.1007/s00705-006-0748-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Susceptibility to scrapie in sheep depends on the host PrP genotype. No data about the linkage of the rare ARK allele to differential scrapie susceptibility are currently available. Several tissues isolated from sheep from an Italian scrapie outbreak and carrying the ARK allele were examined for the presence of the pathological prion protein. A weak positivity was detected only by Western blot in the brainstem of one ARK/ARH sheep. This result shows that the ARK allele does not confer full resistance against scrapie and that the allele needs to be studied further before it can be considered for breeding purposes.

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页码：1875 / 1880

页数：6

相关论文

共 28 条

[1] Low frequency of the scrapile resistance-associated allele and presence of lysine-171 allele of the prion protein gene in Italian Biellese ovine breed [J].

Acutis, PL ;

Sbaiz, L ;

Verburg, F ;

Riina, MV ;

Ru, G ;

Moda, G ;

Caramelli, M ;

Bossers, A .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :3165-3172

[2] Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie [J].

Andréoletti, O ;

Berthon, P ;

Marc, D ;

Sarradin, P ;

Grosclaude, J ;

van Keulen, L ;

Schelcher, F ;

Elsen, JM ;

Lantier, F .

JOURNAL OF GENERAL VIROLOGY, 2000, 81 :3115-3126

[3] The genetics of scrapie in sheep and goats [J].

Baylis, M ;

Goldmann, W .

CURRENT MOLECULAR MEDICINE, 2004, 4 (04) :385-396

[4] IDENTIFICATION OF 5 ALLELIC VARIANTS OF THE SHEEP PRP GENE AND THEIR ASSOCIATION WITH NATURAL SCRAPIE [J].

BELT, PBGM ;

MUILEMAN, IH ;

SCHREUDER, BEC ;

BOSDERUIJTER, J ;

GIELKENS, ALJ ;

SMITS, MA .

JOURNAL OF GENERAL VIROLOGY, 1995, 76 :509-517

[5] Cases of scrapie with unusual features in Norway and designation of a new type, Nor98 [J].

Benestad, SL ;

Sarradin, P ;

Thu, B ;

Schönheit, J ;

Tranulis, MA ;

Bratberg, B .

VETERINARY RECORD, 2003, 153 (07) :202-+

[6] Prion protein gene polymorphisms in healthy and scrapie-affected sheep in Greece [J].

Billinis, C ;

Psychas, V ;

Leontides, L ;

Spyrou, V ;

Argyroudis, S ;

Vlemmas, I ;

Leontides, S ;

Sklaviadis, T ;

Papadopoulos, O .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :547-554

[7] PrP genotype contributes to determining survival times of sheep with natural scrapie [J].

Bossers, A ;

Schreuder, BEC ;

Muileman, IH ;

Belt, PBGM ;

Smits, MA .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :2669-2673

[8] Evidence for the transmission of scrapie to sheep and goats from a vaccine against Mycoplasma agalactiae [J].

Caramelli, M ;

Ru, G ;

Casalone, C ;

Bozzetta, E ;

Acutis, PL ;

Calella, A ;

Forloni, G .

VETERINARY RECORD, 2001, 148 (17) :531-536

[9]

Dawson M, 1998, VET REC, V142, P623

[10] Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep [J].

DeSilva, U ;

Guo, X ;

Kupfer, DM ;

Fernando, SC ;

Pillai, ATV ;

Najar, FZ ;

So, S ;

Fitch, GQ ;

Roe, BA .

CYTOGENETIC AND GENOME RESEARCH, 2003, 102 (1-4) :89-94