"CLASSIC NMR": An In-Situ NMR Strategy for Mapping the Time-Evolution of Crystallization Processes by Combined Liquid-State and Solid-State Measurements

被引：62

作者：

Hughes, Colan E. ^{[1
]}

Williams, P. Andrew ^{[1
]}

Harris, Kenneth D. M. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 34期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

crystal growth; in-situ studies; solid-state nmr spectroscopy; time-dependent processes; AMINOBENZOIC ACIDS; SPECTROSCOPY; POLYMORPHISM; ZWITTERION; KINETICS; SYSTEM; META; RED;

D O I：

10.1002/anie.201404266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new in-situ NMR strategy (termed CLASSIC NMR) for mapping the evolution of crystallization processes is reported, involving simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time. This combined strategy allows complementary information to be obtained on the evolution of both the solid and liquid phases during the crystallization process. In particular, as crystallization proceeds (monitored by solid-state NMR), the solution state becomes more dilute, leading to changes in solution-state speciation and the modes of molecular aggregation in solution, which are monitored by liquid-state NMR. The CLASSIC NMR experiment is applied here to yield new insights into the crystallization of m-aminobenzoic acid.

引用

页码：8939 / 8943

页数：5

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