Many Flavors of Model-Based Meta-Analysis: Part II - Modeling Summary Level Longitudinal Responses

被引：18

作者：

Boucher, Martin ^{[1
]}

Bennetts, Meg ^{[1
]}

机构：

[1] Pfizer Ltd, Dept Pharmacometr, Sandwich, Kent, England

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2018年 / 7卷 / 05期

关键词：

NETWORK METAANALYSIS; RHEUMATOID-ARTHRITIS; EFFICACY; WEIGHT; BENEFIT; TRIALS;

D O I：

10.1002/psp4.12299

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Meta-analyses typically assess comparative treatment response for an end point at specific timepoints across studies. However, during drug development, it is often of interest to understand the response time-course of competitor compounds for a variety of purposes. Examples of such application include informing study design and characterizing the onset, maintenance, and offset of action. This tutorial acts as a "points for consideration" document, reviews relevant literature, and fits a longitudinal model to an example dataset.

引用

页码：288 / 297

页数：10

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