Interactions of Divalent Calcium Ions With Head Groups of Zwitterionic Phosphatidylcholine Liposomal Membranes

被引：0

作者：

Santhosh, Poornima Budime ^{[1
]}

Velikonja, Aljaz ^{[2
,3
]}

Gongadze, Ekaterina ^{[4
]}

Iglic, Ales ^{[4
]}

Kralj-Iglic, Veronika ^{[4
,5
]}

Ulrih, Natasa Poklar ^{[1
,6
]}

机构：

[1] Univ Ljubljana, Dept Food Sci & Technol, Biotech Fac, SI-1000 Ljubljana, Slovenia

[2] Univ Ljubljana, Fac Elect Engn, Lab Biocybernet, SI-1000 Ljubljana, Slovenia

[3] SMARTEH Res & Dev Elect Controlling & Regulating, SI-5220 Tolmin, Slovenia

[4] Univ Ljubljana, Fac Elect Engn, Biophys Lab, SI-1000 Ljubljana, Slovenia

[5] Univ Ljubljana, Fac Hlth Sci, Lab Clin Biophys, SI-1000 Ljubljana, Slovenia

[6] Ctr Excellence Integrated Approaches Chem & Biol, Ljubljana 1000, Slovenia

来源：

ACTA CHIMICA SLOVENICA | 2014年 / 61卷 / 02期

关键词：

Anisotropy; liposomes; bilayer fluidity; iron oxide nanoparticles; electric double layer theory; IRON-OXIDE NANOPARTICLES; WATER DIPOLES; LIPID HEADGROUPS; FLUIDITY; PHOSPHATIDYLSERINE; SATURATION;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of the divalent calcium ions with the zwitterionic lipid membranes was studied by measuring the lipid order parameter which is inversely proportional to the membrane fluidity. Small unilamellar lipid vesicles were prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and then treated with different concentrations of divalent calcium ions. An increase in the order parameter and decrease in the fluidity of the liposomal membranes were observed after treatment with the calcium ions. The presence of positively charged iron oxide nanoparticles in the suspension of liposomes negligibly changed the results. The results of experiments were discussed theoretically within modified Langevin-Poisson-Boltzmann (MLPB) model leading to the conclusion that the membrane fluidity and ordering of the membrane lipids are primarily altered by the accumulation of calcium ions in the region of negatively charged phosphate groups within the head groups of the membrane lipids.

引用

页码：215 / 222

页数：8

共 30 条

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