The Role of miRNAs in the Differentiation of Adipose-Derived Stem Cells

被引：34
作者：
Chen, Jing [1 ,2 ]
Deng, Shuwen [2 ]
Zhang, Shu [2 ]
Chen, Zhaozhao [2 ]
Wu, Songtao [2 ]
Cai, Xiaoxiao [2 ]
Yang, Xingmei [2 ]
Guo, Bin [3 ]
Peng, Qiang [2 ]
机构：
[1] Tongji Univ, Sch Stomatol, Dept Orthodont, Lab Oral Biomed Sci & Translat Med, Shanghai 200072, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610064, Sichuan Provinc, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Inst Stomatol, Beijing 100853, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2014年 / 9卷 / 03期
基金：
中国国家自然科学基金; 国家教育部博士点专项基金资助;
关键词：
adipose-derived stem cells; differentiation; mesenchymal stem cells; miRNA; molecular mechanisms; signaling pathway; BONE MORPHOGENETIC PROTEIN-2; MESENCHYMAL-STROMAL CELLS; REGULATES OSTEOGENIC DIFFERENTIATION; INHIBITS ADIPOGENIC DIFFERENTIATION; NEURON-LIKE DIFFERENTIATION; IN-VITRO DIFFERENTIATION; GROWTH-FACTOR BETA-1; OSTEOBLAST DIFFERENTIATION; MICRORNA EXPRESSION; NUCLEAR EXPORT;
D O I：
10.2174/1574888X09666140213203309
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
MicroRNAs (miRNAs) are defined as a group of endogenous single-stranded noncoding RNAs that have the ability to downregulate gene expression. Recent research suggests that microRNAs (miRNAs) have a critical role in regulating the self-renewal and differentiation of mesenchymal stem cells (MSCs). MSCs, isolated from various adult tissue sources, are able to differentiate into multiple lineages, which are regulated by genetic and epigenetic mechanisms. Adipose- derived stem cells (ADSCs), originating from the vasculature of adipose tissue, share many properties of bone marrow mesenchymal stem cells (BMSCs). With advantages in both method and quantity of acquisition, ADSCs have become an alternative source of seeding cells. It has been shown that a complex system including various growth factors, transcription factors and signaling pathways could temporally control and regulate MSC differentiation into certain types of mature cells. This review briefly summarizes the biology of miRNAs and ADSCs. We then provide basic information regarding the molecular mechanisms of miRNA regulation in MSC differentiation and discuss several examples of that regulation in ADSC differentiation. Last, we provide perspectives on the progress in identification of the functions of miRNAs in ADSC differentiation.
引用
收藏
页码：268 / 279
页数：12
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