UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR

被引：35

作者：

Chiang, An-Jen ^{[1
,2
]}

Li, Chia-Jung ^{[1
,2
,3
]}

Tsui, Kuan-Hao ^{[2
,3
]}

Chang, Chung ^{[4
]}

Chang, Yuan-chin Ivan ^{[5
]}

Chen, Li-Wen ^{[2
]}

Chang, Tsung-Hsien ^{[6
]}

Sheu, Jim Jinn-Chyuan ^{[1
,7
,8
,9
]}

机构：

[1] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 804, Taiwan

[2] Kaohsiung Vet Gen Hosp, Dept Obstet & Gynecol, Kaohsiung 813, Taiwan

[3] Natl Sun Yat Sen Univ, Inst BioPharmaceut Sci, Kaohsiung 804, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Appl Math, Kaohsiung 804, Taiwan

[5] Acad Sinica, Inst Stat Sci, Taipei 115, Taiwan

[6] Natl Def Med Ctr, Dept & Grad Inst Microbiol & Immunol, Taipei 114, Taiwan

[7] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan

[8] China Med Univ, Sch Chinese Med, Taichung 406, Taiwan

[9] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung 807, Taiwan

来源：

BIOMOLECULES | 2021年 / 11卷 / 01期

关键词：

UBE2C; human papillomavirus; cervical cancer; bioinformation; HUMAN-PAPILLOMAVIRUS INFECTION; GENE-EXPRESSION; MICROARRAY ANALYSIS; PATHWAY; RISK; ASSOCIATION; IDENTIFICATION; INHIBITION; SURVIVAL; WOMEN;

D O I：

10.3390/biom11010037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.

引用

页码：1 / 14

页数：14

共 43 条

[1] Targeting mTOR pathway: A new concept in cancer therapy [J].