Binding and distribution of Na2B12H11SH on cellular and subcellular level in tumor tissue of glioma patients in boron neutron capture therapy

被引：32
作者：
Otersen, B
Haritz, D
Grochulla, F
Bergmann, M
Sierralta, W
Gabel, D
机构：
[1] UNIV BREMEN,D-28334 BREMEN,GERMANY
[2] NEUROSURG CLIN,DEPT NEUROSURG,DAMP,GERMANY
[3] ZKH,DEPT NEUROSURG,BREMEN,GERMANY
[4] ZKH BREMAN OST,INST NEUROPATHOL,BREMEN,GERMANY
[5] MAX PLANCK INST EXPT ENDOCRINOL,HANNOVER,GERMANY
来源：
JOURNAL OF NEURO-ONCOLOGY | 1997年 / 33卷 / 1-2期
关键词：
BNCT; BSH; glioma; antibody; immunohistochemistry; cellular/subcellular distribution;
D O I：
10.1023/A:1005789802603
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To determine binding and distribution of Na2B12H11SH (BSH) in glioma tissue in case of boron neutron capture therapy, an antibody to this compound was produced and used in immunohistochemical investigations. It is possible to trace BH in immunohistochemistry, because BSH is firmly bound to the glioma tissue. The antibody against BSH is specific for that antigen, as tumor tissue from patients without BSH administration did not stain. In areas of healthy brain from BSH infused patients, no staining of tissue was detectable. In tumor tissues, BSH is presenting as a strong staining in cytoplasm and nucleus areas.
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收藏
页码：131 / 139
页数：9
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