Investigation of inflammation inducing substances in PM2.5 particles by an elimination method using thermal decomposition

被引：6

作者：

He, Miao ^{[1
]}

Ichinose, Takamichi ^{[2
]}

Ito, Tomohiro ^{[3
]}

Toriba, Akira ^{[4
]}

Yoshida, Seiichi ^{[2
]}

Kaori, Sadakane ^{[2
]}

Nishikawa, Masataka ^{[5
]}

Sun, Guifan ^{[1
]}

Shibamoto, Takayuki ^{[6
]}

机构：

[1] China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Key Lab Environm Hlth Damage Res & Assessment, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China

[2] Oita Univ Nursing & Hlth Sci, Dept Hlth Sci, Oita OITA 870120, Japan

[3] Natl Inst Environm Studies, Ctr Hlth & Environm Risk Res, Tsukuba, Ibaraki, Japan

[4] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa, Japan

[5] Natl Inst Environm Studies, Environm Chem Div, Tsukuba, Ibaraki, Japan

[6] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA

来源：

ENVIRONMENTAL TOXICOLOGY | 2019年 / 34卷 / 10期

关键词：

lung inflammation; metals; PAHQs; PM2; 5; thermal decomposition; POLYCYCLIC AROMATIC-HYDROCARBONS; OXIDATIVE STRESS; DEVELOPMENTAL TOXICITY; PARTICULATE MATTER; AIR-POLLUTION; URBAN PM2.5; FINE; EXPRESSION; LUNG; MACROPHAGES;

D O I：

10.1002/tox.22816

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The substances associated with PM2.5-induced inflammatory response were investigated using an elimination method. PM2.5 were heated at temperatures of 120, 250, and 360 degrees C. The results demonstrated microbial substances such as LPS and b-glucan, and chemicals including BaP, 1,2-NQ, and 9,10-PQ were reduced drastically in PM2.5 heated at 120 degrees C. On the other hand, DBA, 7,12-BAQ, and BaP-1,6-Q were not noticeably reduced. Most of these substances had disappeared in PM2.5 heated at 250 degrees C and 360 degrees C. Metals (eg, Fe, Cu, Cr, Ni) in PM2.5 exhibited a slight thermo-dependent increase. RAW264.7 macrophages with or without NAC were exposed to unheated PM2.5, oxidative stress-related and unrelated inflammatory responses were induced. PM2.5-induced lung inflammation in mice is caused mainly by thermo-sensitive substances (LPS, b-glucan, BaP, 1,2-NQ, 9,10-PQ, etc.). Also, a slight involvement of thermo-resistant substances (DBA, 7,12-BAQ, BaP-1,6-Q, etc.) and transition metals was observed. The thermal decomposition method could assist to evaluate the PM2.5-induded lung inflammation.

引用

页码：1137 / 1148

页数：12