A New Golden Age of Natural Products Drug Discovery

被引：529

作者：

Shen, Ben ^{[1
,2
,3
,4
]}

机构：

[1] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA

[2] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA

[3] Scripps Res Inst, Nat Prod Lib Initiat, Jupiter, FL 33458 USA

[4] Cent S Univ, Xiangya Int Acad Translat Med, Changsha 410013, Hunan, Peoples R China

来源：

CELL | 2015年 / 163卷 / 06期

关键词：

ARTEMISININ; IVERMECTIN; QINGHAOSU;

D O I：

10.1016/j.cell.2015.11.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 2015 Nobel Prize in Physiology or Medicine has been awarded to William C. Campbell, Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases. With the recent technological advances, a New Golden Age of natural products drug discovery is dawning.

引用

页码：1297 / 1300

页数：4

共 13 条

[1] Mass spectrometry of natural products: current, emerging and future technologies [J].

Bouslimani, Amina ;

Sanchez, Laura M. ;

Garg, Neha ;

Dorrestein, Pieter C. .

NATURAL PRODUCT REPORTS, 2014, 31 (06) :718-729

[2] Chemical-biogeographic survey of secondary metabolism in soil [J].

Charlop-Powers, Zachary ;

Owen, Jeremy G. ;

Reddy, Boojala Vijay B. ;

Ternei, Melinda A. ;

Brady, Sean F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (10) :3757-3762

[3] Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis [J].

Ikeda, H ;

Nonomiya, T ;

Usami, M ;

Ohta, T ;

Ömura, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9509-9514

[4] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].

KLAYMAN, DL .

SCIENCE, 1985, 228 (4703) :1049-1055

[5] Drug Discovery and Natural Products: End of an Era or an Endless Frontier? [J].

Li, Jesse W. -H. ;

Vederas, John C. .

SCIENCE, 2009, 325 (5937) :161-165

[6] A new antibiotic kills pathogens without detectable resistance [J].

Ling, Losee L. ;

Schneider, Tanja ;

Peoples, Aaron J. ;

Spoering, Amy L. ;

Engels, Ina ;

Conlon, Brian P. ;

Mueller, Anna ;

Schaeberle, Till F. ;

Hughes, Dallas E. ;

Epstein, Slava ;

Jones, Michael ;

Lazarides, Linos ;

Steadman, Victoria A. ;

Cohen, Douglas R. ;

Felix, Cintia R. ;

Fetterman, K. Ashley ;

Millett, William P. ;

Nitti, Anthony G. ;

Zullo, Ashley M. ;

Chen, Chao ;

Lewis, Kim .

NATURE, 2015, 517 (7535) :455-+

[7] Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 [J].

Newman, David J. ;

Cragg, Gordon M. .

JOURNAL OF NATURAL PRODUCTS, 2012, 75 (03) :311-335

[8] The life and times of ivermectin - a success story [J].

Omura, S ;

Crump, A .

NATURE REVIEWS MICROBIOLOGY, 2004, 2 (12) :984-989

[9] Ivermectin: panacea for resource-poor communities? [J].

Omura, Satoshi ;

Crump, Andy .

TRENDS IN PARASITOLOGY, 2014, 30 (09) :445-455

[10] Microbial metabolites: 45 years of wandering, wondering and discovering [J].

Omura, Satoshi .

TETRAHEDRON, 2011, 67 (35) :6420-6459

← 1 2 →