Synthesis of Dibenzodiazepinones via Tandem Copper(I)-Catalyzed C-N Bond Formation

被引：21

作者：

Gawande, Sachin D. ^{[1
]}

Kavala, Veerababurao ^{[1
]}

Zanwar, Manoj R. ^{[1
]}

Kuo, Chun-Wei ^{[1
]}

Huang, Wen-Chang ^{[1
]}

Kuo, Ting-Shen ^{[1
]}

Huang, Hsiu-Ni ^{[1
]}

He, Chiu-Hui ^{[1
]}

Yao, Ching-Fa ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 11-12期

关键词：

C-N bond formation; copper catalysts; dibenzodiazepinones; tandem processes; Ullmann coupling; SMILES REARRANGEMENT; QUINAZOLINONES; DERIVATIVES; OLANZAPINE; AMIDATION; LACTAMS; ALKYNES; AZIDE;

D O I：

10.1002/adsc.201301020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient, one-pot method for the synthesis of dibenzodiazepinone derivatives involving copper-catalyzed tandem C-N bond formation is reported. The use of various halo amide and 2-iodoaniline derivatives permitted the synthesis of an array of dibenzodiazepinone derivatives in moderate to good yields. Moreover, a dibenzodiazepinone derivative {2-(11-oxo-5H-dibenzo[b,e][1,4]diazepin-10(11H)-yl)benzonitrile} was utilized to synthesize the triazapentacyclic ring derivative {12-chloro-8,15,22-triazapentacyclo[13.7.0.0(2,7).0(9,14).0(16,21)]docosa-1(22),2,4,6,9(14),10,12,16(21),17,19-decaene}.

引用

页码：2599 / 2608

页数：10

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