A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population

Background: Coronary artery disease (CAD) is one of the most common forms of heart diseases. Monocyte chemoattractant protein-1 gene (MCP-1, CCL2) has been considered one of the candidate genes that play a role in atherogenesis of CAD. Recently, the association of a single nucleotide polymorphism (SNP) in the MCPA gene promoter (-2518A>G) and CAD has been investigated with controversial results. Methods: The -2518A>G polymorphism of MCP-1 was determined in 502 CAD patients and 410 control subjects to investigate the possible involvement of MCP-1 in CAD. Results: No significant differences in the genotype or allele frequencies were revealed between subjects with and without CAD (P=0.581 and 0.310, respectively). Further stratification analysis by gender or age and analysis of clinical features in relation to myocardial infarction also yielded negative results. Conclusion: -2518A>G polymorphism of MCP-1 does not seem to contribute substantially to CAD in Han Chinese. (C) 2009 Elsevier B.V. All rights reserved.