Diagnostics and therapy of AA amyloidosis

被引：6

作者：

Blank, N. ^{[1
]}

Lorenz, H. M. ^{[1
]}

机构：

[1] Univ Klinikum Heidelberg, Med Klin 5, Sekt Rheumatol, D-69120 Heidelberg, Germany

来源：

PATHOLOGE | 2009年 / 30卷 / 03期

关键词：

Amyloidosis; Rheumatic disease; TNF alpha; Familial Mediterranean fever; Colchicine; Periodic syndrome; FAMILIAL MEDITERRANEAN FEVER; PERIODIC SYNDROME TRAPS; GRANULOMATOUS ARTHRITIS; SYSTEMIC AMYLOIDOSIS; BLAU-SYNDROME; TNF RECEPTOR; MUTATIONS; DISEASE; URTICARIA; PROTEIN;

D O I：

10.1007/s00292-009-1140-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

AA amyloidosis can be the consequence of any chronic inflammatory disorder. It is most commonly associated with chronic inflammatory rheumatic, pulmonary or gastrointestinal diseases, familial Mediterranean fever or other rare periodic syndromes. AA amyloidosis often affects the kidneys, gastrointestinal tract and the heart. Effective therapy of the underlying disease can normalize the inflammatory reaction and can slow or inhibit the deterioration of organ function if the diagnosis is made at an early stage of the disease. In rheumatoid diseases and in some periodic syndromes the use of antibodies against TNF alpha or IL-1 beta might be helpful. Patients with familial Mediterranean fever should regularly take colchicine to prevent attacks and to reduce the risk for development or progression of AA amyloidosis. Eprodisate is currently being investigated for AA amyloidosis and renal involvement.

引用

页码：219 / 225

页数：7

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