An efficient synthesis of 2,3,5-trisubstituted furans from α,β-unsaturated ketones

被引：43

作者：

Brown, CD ^{[1
]}

Chong, JM ^{[1
]}

Shen, LX ^{[1
]}

机构：

[1] Univ Waterloo, Guelph Waterloo Ctr Grad Work Chem, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

TETRAHEDRON | 1999年 / 55卷 / 50期

基金：

加拿大自然科学与工程研究理事会;

关键词：

furans; alkynes; cyclization; regioselective;

D O I：

10.1016/S0040-4020(99)00898-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, regioselective synthesis of 2,3,5-trisubstituted furans is described. Conjugate addition of alkynylboronates to alpha,beta-unsaturated ketones, followed by acid-catalyzed cyclization of the resulting gamma-alkynyl ketones affords trisubstituted furans in 31-97% overall yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：14233 / 14242

页数：10

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