Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy

In France there is no official recommendation for the drug management of nausea and vomiting during pregnancy. In the USA, Canada and Australia, vitamin B6 is officially recommended in the treatment of mild to moderate pregnancy sickness and vomiting. Indeed, some studies have shown some effectiveness of oral vitamin B6, most often in combination with doxylamine, in comparison with a placebo. In addition, the harmlessness of oral vitamin B6 during pregnancy has been established for doses up to 40-60 mg/day, mainly in combination with doxylamine (40 mg/40 mg). Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10 mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine. (C) 2020 Elsevier Masson SAS. All rights reserved.