Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy

被引:2
|
作者
Pecriaux, C. [1 ]
机构
[1] Sorbonne Univ, GHU AP HP, Ctr Reference Agents Teratogenes CRAT, DMU ESPRIT Epidemiol & Biostat Sante Publ Pharm P, Site Trousseau 26 Ave Dr Netter, F-75571 Paris 12, France
来源
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE | 2020年 / 48卷 / 11期
关键词
Vitamine B6; Grossesse; Nausees; Vomissements; Antiemetique; DOUBLE-BLIND; PYRIDOXINE;
D O I
10.1016/j.gofs.2020.09.005
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
In France there is no official recommendation for the drug management of nausea and vomiting during pregnancy. In the USA, Canada and Australia, vitamin B6 is officially recommended in the treatment of mild to moderate pregnancy sickness and vomiting. Indeed, some studies have shown some effectiveness of oral vitamin B6, most often in combination with doxylamine, in comparison with a placebo. In addition, the harmlessness of oral vitamin B6 during pregnancy has been established for doses up to 40-60 mg/day, mainly in combination with doxylamine (40 mg/40 mg). Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10 mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine. (C) 2020 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:840 / 843
页数:4
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