5-Fluorouracil trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels:: in vitro drug delivery studies

被引：51

作者：

García, O ^{[1
]}

Blanco, MD ^{[1
]}

Martín, JA ^{[1
]}

Teijón, JM ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol 3, E-28040 Madrid, Spain

来源：

EUROPEAN POLYMER JOURNAL | 2000年 / 36卷 / 01期

关键词：

hydrogel; poly(2-hydroxyethyl methacrylate-co-acrylamide); controlled release; swelling; 5-fluorouracil;

D O I：

10.1016/S0014-3057(99)00037-3

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The influence of gel formulation on the diffusion of 5-fluorouracil (5-FU) included in poly(2-hydroxyethyl methacrylate-co-acrylamide) (poly(HEMA-co-A)) hydrogels is reported. The synthesis of these copolymers, in different monomeric proportions, each one of them crosslinked with different proportions of ethylenglycol dimethacrylate (90 HEMA/10 A, 75 HEMA/25 A and 50 HEMA/50 A), allows the inclusion of 5-FU in the feed mixture of polymerization, up to 16 mg/disc, without any chemical drug alteration; and it also makes possible the control of its release over a wide range of release times that vary between 7 h and 9 days, just by modulating the crosslinking: degree of the copolymer as well as their comonomeric composition, maintaining sufficiently high hydrate degrees (66-24 wt%). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：111 / 122

页数：12

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