Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection

被引：26

作者：

Zilber, Eva ^{[1
]}

Martin, Genevieve E. ^{[1
]}

Willberg, Christian B. ^{[1
,2
]}

Fox, Julie ^{[3
,11
]}

Nwokolo, Nneka ^{[4
]}

Fidler, Sarah ^{[5
,6
,9
]}

Frater, John ^{[1
,2
,7
,10
]}

Lever, Andrew ^{[8
]}

Wills, Mark ^{[8
]}

Weber, Jonathan ^{[9
]}

Fidler, Sarah ^{[5
,6
,9
]}

Frater, John ^{[1
,2
,7
,10
]}

Dorrell, Lucy ^{[10
]}

Malim, Mike ^{[11
]}

Fox, Julie ^{[3
,11
]}

Gupta, Ravi ^{[12
]}

Jolly, Clare ^{[12
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford, England

[2] Natl Inst Hlth Res Biomed Res Ctr, Oxford, England

[3] Guys & St Thomas NHS Trust

[4] Chelsea & Westminster Hosp, London, England

[5] Imperial Coll, Wright Fleming Inst, Div Med, London, England

[6] Imperial Coll, Natl Inst Hlth Res, Biomed Res Ctr, London, England

[7] Oxford Martin Sch, Oxford, England

[8] Univ Cambridge, Cambridge, England

[9] Imperial Coll, London, England

[10] Univ Oxford, Oxford, England

[11] Kings Coll London, London, England

[12] UCL, London, England

来源：

AIDS | 2019年 / 33卷 / 07期

关键词：

T-CELLS; EXPRESSION;

D O I：

10.1097/QAD.0000000000002165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.

引用

页码：1253 / 1256

页数：4

共 50 条

[31] Nanobodies targeting the interaction interface of programmed death receptor 1 (PD-1)/PD-1 ligand 1 (PD-1/PD-L1)
Wen, Biyan
Zhao, Lin
Wang, Yuchu
Qiu, Chuangnan
Xu, Zhimin
Huang, Kunling
Zhu, He
Li, Zemin
Li, Huangjin
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 2020, 50 (03): : 252 - 259
[32] Expression of PD-1 and Tim-3 is increased in skin of patients with bullous pemphigoid and pemphigus vulgaris
Ernst, N.
Friedrich, M.
Bieber, K.
Kasperkiewicz, M.
Gross, N.
Sadik, C. D.
Zillikens, D.
Schmidt, E.
Ludwig, R. J.
Hartmann, K.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2021, 35 (02) : 486 - 492
[33] Implications of PD-1, Tim-3, and TIGIT Expression for Cancer Immunity and Pancreatic Cancer Prognosis
Nakayama, Chieri
Tanoue, Kiyonori
Idichi, Tetsuya
Shimomura, Hiroki
Kita, Yoshiaki
Hozaka, Yuto
Shinden, Yoshiaki
Matsushita, Daisuke
Nakajo, Akihiro
Arigami, Takaaki
Mataki, Yuko
Kurahara, Hiroshi
Ohtsuka, Takao
ANTICANCER RESEARCH, 2022, 42 (07) : 3373 - 3380
[34] CTLA-4, PD-1 and TIM-3 expression predominantly downregulated in MS patients
Mohammadzadeh, Adel
Rad, Isa Abdi
Ahmadi-Salmasi, Babak
JOURNAL OF NEUROIMMUNOLOGY, 2018, 323 : 105 - 108
[35] Programmed Death 1 (PD-1) and PD-1 Ligand (PD-L1) Expression in Chronic Apical Periodontitis
Rezende Delgado, Ronan Jacques
Ramos Pinheiro, Claudia
Gasparoto, Thais Helena
Sipert, Carla Renata
de Moraes, Ivaldo Gomes
Garcia, Roberto Brandao
Bramante, Clovis Monteiro
Bernardineli, Norberti
Nishiyama, Celso Kenji
da Silva, Joao Santana
Torres, Sergio Aparecido
Garlet, Gustavo Ponnpernnaier
Campanelli, Ana Paula
EUROPEAN ENDODONTIC JOURNAL, 2019, 4 (01): : 3 - 8
[36] PROGRAMMED DEATH-1 (PD-1), PROGRAMMED DEATH-LIGAND 1 (PD-L1) EXPRESSION IN UTERINE GRADE 3 ENDOMETRIOID ADENOCANCER
Gulec, U. Kucukgoz
Bagir, E.
Paydas, S.
Guzel, A. B.
Khatib, G.
Seydaoglu, G.
Vardar, M. A.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 1126 - 1126
[37] Outcomes of Programmed Cell Death Protein 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1) Inhibitor Therapy in HIV Patients with Advanced Cancer
Bari, Shahla
Muzaffar, Jameel
Chan, Austin
Jain, Sanjay R.
Haider, Ahmad M.
Curry, Marjorie Adams
Hostler, Christopher J.
JOURNAL OF ONCOLOGY, 2019, 2019
[38] PROGRAMMED DEATH-1 (PD-1), PROGRAMMED DEATH-LIGAND 1 (PD-L1) EXPRESSION IN UTERINE CARCINOSARCOMAS
Gulec, U. Kucukgoz
Bagir, E.
Paydas, S.
Seydaoglu, G.
Guzel, A. B.
Vardar, M. A.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 1125 - 1125
[39] PROGRAMMED DEATH-1 (PD-1), PROGRAMMED DEATH-LIGAND 1 (PD-L1) EXPRESSION IN UTERINE CARCINOSARCOMAS
Gulec, U. Kucukgoz
Bagir, E.
Paydas, S.
Seydaoglu, G.
Guzel, A. B.
Vardar, M. A.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 219 - 219
[40] Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
Jin, Hyun-Tak
Anderson, Ana C.
Tan, Wendy G.
West, Erin E.
Ha, Sang-Jun
Araki, Koichi
Freeman, Gordon J.
Kuchroo, Vijay K.
Ahmed, Rafi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) : 14733 - 14738

← 1 2 3 4 5 →