Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection

被引：26

作者：

Zilber, Eva ^{[1
]}

Martin, Genevieve E. ^{[1
]}

Willberg, Christian B. ^{[1
,2
]}

Fox, Julie ^{[3
,11
]}

Nwokolo, Nneka ^{[4
]}

Fidler, Sarah ^{[5
,6
,9
]}

Frater, John ^{[1
,2
,7
,10
]}

Lever, Andrew ^{[8
]}

Wills, Mark ^{[8
]}

Weber, Jonathan ^{[9
]}

Fidler, Sarah ^{[5
,6
,9
]}

Frater, John ^{[1
,2
,7
,10
]}

Dorrell, Lucy ^{[10
]}

Malim, Mike ^{[11
]}

Fox, Julie ^{[3
,11
]}

Gupta, Ravi ^{[12
]}

Jolly, Clare ^{[12
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford, England

[2] Natl Inst Hlth Res Biomed Res Ctr, Oxford, England

[3] Guys & St Thomas NHS Trust

[4] Chelsea & Westminster Hosp, London, England

[5] Imperial Coll, Wright Fleming Inst, Div Med, London, England

[6] Imperial Coll, Natl Inst Hlth Res, Biomed Res Ctr, London, England

[7] Oxford Martin Sch, Oxford, England

[8] Univ Cambridge, Cambridge, England

[9] Imperial Coll, London, England

[10] Univ Oxford, Oxford, England

[11] Kings Coll London, London, England

[12] UCL, London, England

来源：

AIDS | 2019年 / 33卷 / 07期

关键词：

T-CELLS; EXPRESSION;

D O I：

10.1097/QAD.0000000000002165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.

引用

页码：1253 / 1256

页数：4

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