Chromone Glycosides and Hepatoprotective Constituents of Hypericum erectum

被引：15

作者：

An, Ren Bo ^{[2
]}

Jeong, Gil Saeng ^{[3
]}

Beom, Jin-Seon ^{[1
]}

Sohn, Dong Hwan ^{[1
]}

Kim, Youn Chul ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

[2] Yanbian Univ, Coll Pharm, Key Lab Organism Funct Factors Changbai Mt, Yanji 133002, Jilin Province, Peoples R China

[3] Wonkwang Univ, Zoonosis Res Ctr, Iksan 570749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 10期

关键词：

Hypericum erectum; Guttiferae; Hepatoprotective activity; Chromone glycosides; Hyperimone A; Hyperimone B; TACRINE-INDUCED CYTOTOXICITY; DERIVATIVES; CULTURES;

D O I：

10.1007/s12272-009-2008-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC50 values of 160.2 +/- 0.6 mu M and 217.7 +/- 1.3 mu M, respectively, against tacrine-induced cytotoxicity in HepG2 cells.

引用

页码：1393 / 1397

页数：5

共 20 条

[1] Hepatoprotective compounds of the roots of Cudrania tricuspidata on tacrine-induced cytotoxicity in Hep G2 cells
An, RB
Sohn, DH
Kim, YC
[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (04) : 838 - 840
[2] Cytoprotective constituent of Hoveniae Lignum on both Hep G2 cells and rat primary hepatocytes
An, Ren-Bo
Park, Eun-Jeon
Jeong, Gil-Saeng
Sohn, Dong-Hwan
Kim, Youn-Chul
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (06) : 674 - 677
[3] BAE KH, 2002, MED PLANTS KOREA
[4] BIFLAVONOIDS IN HYPERICUM-PERFORATUM .1. ISOLATION OF I3,II8-BIAPIGENIN
BERGHOFER, R
HOLZL, J
[J]. PLANTA MEDICA, 1987, (02) : 216 - 217
[5] FURTHER PHOROGLUCIN AND ALPHA-PYRONE DERIVATIVES FROM HELICHRYSUM TYPES
BOHLMANN, F
MISRA, LN
JAKUPOVIC, J
[J]. PLANTA MEDICA, 1984, 50 (02) : 174 - 176
[6] Edoute Y, 2001, ISRAEL MED ASSOC J, V3, P382
[7] FOO LY, 1989, PHYTOCHEMISTRY, V28, P1743, DOI 10.1016/S0031-9422(00)97836-1
[8] Patulosides A and B, novel xanthone glycosides from cell suspension cultures of Hypericum patulum
Ishiguro, K
Yamamota, R
Oku, H
[J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (06): : 906 - 908
[9] STUDIES ON RHUBARB (RHEI-RHIZOMA) .16. CHROMONE GLUCOSIDES FROM RHUBARB
KASHIWADA, Y
NONAKA, G
NISHIOKA, I
[J]. PHYTOCHEMISTRY, 1990, 29 (03) : 1007 - 1009
[10] Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells
Kim, YC
An, RB
Yoon, NY
Nam, TJ
Choi, JS
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (12) : 1376 - 1380

← 1 2 →