Chromone Glycosides and Hepatoprotective Constituents of Hypericum erectum

被引：18

作者：

An, Ren Bo ^{[2
]}

Jeong, Gil Saeng ^{[3
]}

Beom, Jin-Seon ^{[1
]}

Sohn, Dong Hwan ^{[1
]}

Kim, Youn Chul ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

[2] Yanbian Univ, Coll Pharm, Key Lab Organism Funct Factors Changbai Mt, Yanji 133002, Jilin Province, Peoples R China

[3] Wonkwang Univ, Zoonosis Res Ctr, Iksan 570749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 10期

关键词：

Hypericum erectum; Guttiferae; Hepatoprotective activity; Chromone glycosides; Hyperimone A; Hyperimone B; TACRINE-INDUCED CYTOTOXICITY; DERIVATIVES; CULTURES;

D O I：

10.1007/s12272-009-2008-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC50 values of 160.2 +/- 0.6 mu M and 217.7 +/- 1.3 mu M, respectively, against tacrine-induced cytotoxicity in HepG2 cells.

引用

页码：1393 / 1397

页数：5

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